2023 GRNs for Development Course at MBL
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2023 GRNs for Development Course at MBL

The Marine Biological Laboratory is offering a course, Gene Regulatory Networks for Development from October 8-20, 2023.

Applications can be submitted HERE.

The Application due date is July 21, 2023.

Directors: Titus Brown, University of California, Davis and Veronica Hinman, Carnegie Mellon University

Course Description

Gene regulatory networks (GRNs) are key to the genomic control of development in animals and plants. To study GRNs requires insights from various research fields, including systems biology, developmental and evolutionary biology, as well as functional genomics, and provides an integrative approach to fundamental research questions in biology. This course introduces the concepts of GRNs, and teaches experimental and computational methods used to study them, through highly interactive lectures, discussions, group projects, and practical tutorials. We will cover a broad range of topics, including transcriptional control systems, the structural organization of hierarchical networks, developmental functions of GRN circuit modules, GRN evolution, and computational modeling using BioTapestry as well as Boolean and quantitative mathematical approaches. Students will learn how to generate GRN models based on data extracted from the literature, and will generate computational models to analyze dynamic circuit behavior. We will present and discuss a broad range of experimental approaches and how they are effectively used for studying gene regulation and developmental GRNs. Examples of experimentally solved developmental GRNs from a variety of organisms, such as flies, sea urchins, frogs, chicken, and mice, will be explored. Students are encouraged to share their research projects in a poster session, and to discuss with course faculty how to apply the approaches taught in the course to their own research questions. The course is intended for advanced graduate students, postdoctoral scholars, and faculty.

Course Lecturers

  • Leslie Babonis, Cornell
  • Scott Barolo, University of Michigan 
  • James Briscoe, Crick Institute
  • Doug Erwin, Smithsonian
  • Roberto Feuda, University of Leicester
  • William Longabaugh, Institute for Systems Biology
  • Hui-Chun Lu (Grace), University College London
  • Megan Martik, UC Berkeley
  • Paola Oliveri, University College London
  • Nipam Patel, Marine Biological Laboratory
  • Mark Rebeiz, University of Pittsburgh
  • Crystal Rogers, UC Davis Andrea Streit, King's College London
  • Sarah Tulin, Canisius University
  • Zeba Wunderlich, Boston University

Last Updated: 2023-07-12