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PLoS Biol 2013 Oct 01;1110:e1001696. doi: 10.1371/journal.pbio.1001696.
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The impact of gene expression variation on the robustness and evolvability of a developmental gene regulatory network.

Garfield DA , Runcie DE , Babbitt CC , Haygood R , Nielsen WJ , Wray GA .

Regulatory interactions buffer development against genetic and environmental perturbations, but adaptation requires phenotypes to change. We investigated the relationship between robustness and evolvability within the gene regulatory network underlying development of the larval skeleton in the sea urchin Strongylocentrotus purpuratus. We find extensive variation in gene expression in this network throughout development in a natural population, some of which has a heritable genetic basis. Switch-like regulatory interactions predominate during early development, buffer expression variation, and may promote the accumulation of cryptic genetic variation affecting early stages. Regulatory interactions during later development are typically more sensitive (linear), allowing variation in expression to affect downstream target genes. Variation in skeletal morphology is associated primarily with expression variation of a few, primarily structural, genes at terminal positions within the network. These results indicate that the position and properties of gene interactions within a network can have important evolutionary consequences independent of their immediate regulatory role.

PubMed ID: 24204211
PMC ID: PMC3812118
Article link: PLoS Biol
Grant support: [+]

Species referenced: Echinodermata
Genes referenced: arid3a erg foxb1 gata6 impact LOC100887844 LOC100893907 LOC105438357 LOC115919910 LOC582915 tgif2l

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References [+] :
Balhoff, Evolutionary analysis of the well characterized endo16 promoter reveals substantial variation within functional sites. 2005, Pubmed, Echinobase