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ECB-ART-41603
Genome Biol 2010 Jan 01;114:R44. doi: 10.1186/gb-2010-11-4-r44.
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Restriction Site Tiling Analysis: accurate discovery and quantitative genotyping of genome-wide polymorphisms using nucleotide arrays.

Pespeni MH , Oliver TA , Manier MK , Palumbi SR .


Abstract
High-throughput genotype data can be used to identify genes important for local adaptation in wild populations, phenotypes in lab stocks, or disease-related traits in human medicine. Here we advance microarray-based genotyping for population genomics with Restriction Site Tiling Analysis. The approach simultaneously discovers polymorphisms and provides quantitative genotype data at 10,000s of loci. It is highly accurate and free from ascertainment bias. We apply the approach to uncover genomic differentiation in the purple sea urchin.

PubMed ID: 20403197
PMC ID: PMC2884547
Article link: Genome Biol


Genes referenced: fst LOC100887844 pklr


Article Images: [+] show captions
References [+] :
Akey, Interrogating a high-density SNP map for signatures of natural selection. 2002, Pubmed