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Echinobase
ECB-ART-41399
FEBS Lett 2009 Dec 17;58324:3948-58. doi: 10.1016/j.febslet.2009.11.060.
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Modularity and design principles in the sea urchin embryo gene regulatory network.

Peter IS , Davidson EH .


Abstract
The gene regulatory network (GRN) established experimentally for the pre-gastrular sea urchin embryo provides causal explanations of the biological functions required for spatial specification of embryonic regulatory states. Here we focus on the structure of the GRN which controls the progressive increase in complexity of territorial regulatory states during embryogenesis; and on the types of modular subcircuits of which the GRN is composed. Each of these subcircuit topologies executes a particular operation of spatial information processing. The GRN architecture reflects the particular mode of embryogenesis represented by sea urchin development. Network structure not only specifies the linkages constituting the genomic regulatory code for development, but also indicates the various regulatory requirements of regional developmental processes.

PubMed ID: 19932099
PMC ID: PMC2810318
Article link: FEBS Lett
Grant support: [+]

Genes referenced: LOC100887844 LOC575170

References [+] :
Amore, cis-Regulatory control of cyclophilin, a member of the ETS-DRI skeletogenic gene battery in the sea urchin embryo. 2006, Pubmed, Echinobase