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FIGURE 2:. Wild-type Ect2 induces hypercontractility during cytokinesis. (A) Sand dollar embryo expressing 3xGFP SpEct2 WT(white) and mCh-H2B (red), single section. Cells 1–4 exhibit various behaviors, likely due to variation in the amount of Ect2 mRNA inherited after injection: cell 1 cleaves normally, and cells 2–4 are hyperactive. Open arrowheads point out instances of cortical Ect2; solid arrowheads follow the midzone in cell 2 as it slips when the cell contracts. See Supplemental Video S4. (B) Eight-cell sand dollar embryo coexpressing eGFP-rGBD and wt SpEct2, projection of 15 1-μm sections; these cells exhibit broad furrow zones and ectopic Rho activation. Times are minutes:seconds after filming began. Image published in: Su KC et al. (2014) Image downloaded from an Open Access article in PubMed Central. © 2014 Su et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). Larger Image Printer Friendly View

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