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Echinobase
ECB-ART-46751
Nat Prod Commun 2017 Feb 01;122:261-262.
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Isolation and Characterization of Antiangiogenesis Compounds from the Fungus Aspergillus terreus Associated with Apostichopus japonicus Using Zebrafish Assay.

Qi J, Zhao B, Zhao P, Jia A, Zhang Y, Liu X, Liu C, Zhang L, Xia X.


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Three compouds, (+)-butyrolactone IV (1), butyrolactone I (2) and terrelactone A (3) were isolated from the fungus Aspergillus terreus associated with Apostichopusjaponicus from the Yellow Sea in China; their structures were elucidated by spectral methods. Compounds I and 2 were shown to have moderate antiangiogenesis activity when tested using-the zebrafish assay. This is the first report of butyrolactones with antiangiogenesis activity.

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Genes referenced: LOC100887844