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2016 Jun 01;51-2:100-106. doi: 10.1166/msr.2016.1052.
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ADP-ribosyl cyclases regulate early development of the sea urchin.
Ramakrishnan L
,
Uhlinger K
,
Dale L
,
Hamdoun A
,
Patel S
.
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ADP-ribosyl cyclases are multifunctional enzymes involved in the metabolism of nucleotide derivatives necessary for Ca2+ signalling such as cADPR and NAADP. Although Ca2+ signalling is a critical regulator of early development, little is known of the role of ADP-ribosyl cyclases during embryogenesis. Here we analyze the expression, activity and function of ADP-ribosyl cyclases in the embryo of the sea urchin - a key organism for study of both Ca2+ signalling and embryonic development. ADP-ribosyl cyclase isoforms (SpARC1-4) showed unique changes in expression during early development. These changes were associated with an increase in the ratio of cADPR:NAADP production. Over-expression of SpARC4 (a preferential cyclase) disrupted gastrulation. Our data highlight the importance of ADP-ribosyl cyclases during embryogenesis.
Berridge,
The versatility and universality of calcium signalling.
2000, Pubmed
Berridge,
The versatility and universality of calcium signalling.
2000,
Pubmed
Berridge,
Metabolism of the novel Ca2+-mobilizing messenger nicotinic acid-adenine dinucleotide phosphate via a 2'-specific Ca2+-dependent phosphatase.
2002,
Pubmed
Churamani,
Molecular characterization of a novel intracellular ADP-ribosyl cyclase.
2007,
Pubmed
,
Echinobase
Churamani,
Molecular characterization of a novel cell surface ADP-ribosyl cyclase from the sea urchin.
2008,
Pubmed
,
Echinobase
Churamani,
The signaling protein CD38 is essential for early embryonic development.
2012,
Pubmed
Clapper,
Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol trisphosphate.
1987,
Pubmed
,
Echinobase
Davis,
Ca(2+) signaling occurs via second messenger release from intraorganelle synthesis sites.
2008,
Pubmed
,
Echinobase
De Flora,
Autocrine and paracrine calcium signaling by the CD38/NAD+/cyclic ADP-ribose system.
2004,
Pubmed
Ettensohn,
The invertebrate deuterostomes: an introduction to their phylogeny, reproduction, development, and genomics.
2004,
Pubmed
Galione,
Redundant mechanisms of calcium-induced calcium release underlying calcium waves during fertilization of sea urchin eggs.
1993,
Pubmed
,
Echinobase
Gökirmak,
Localization and substrate selectivity of sea urchin multidrug (MDR) efflux transporters.
2012,
Pubmed
,
Echinobase
Graeff,
Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine nicotinic acid adenine dinucleotide phosphate (NAADP) synthesis and hydrolysis activities.
2006,
Pubmed
Graeff,
Cyclic GMP-dependent and -independent effects on the synthesis of the calcium messengers cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate.
1998,
Pubmed
,
Echinobase
Howard,
Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38.
1993,
Pubmed
Jin,
CD38 is critical for social behaviour by regulating oxytocin secretion.
2007,
Pubmed
Kume,
Role of inositol 1,4,5-trisphosphate receptor in ventral signaling in Xenopus embryos.
1997,
Pubmed
Lee,
Cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate (NAADP) as messengers for calcium mobilization.
2012,
Pubmed
Lee,
Calcium mobilization by dual receptors during fertilization of sea urchin eggs.
1993,
Pubmed
,
Echinobase
Lee,
Enzymatic functions and structures of CD38 and homologs.
2000,
Pubmed
Malavasi,
Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology.
2008,
Pubmed
Moreau,
Calcium signalling during neural induction in Xenopus laevis embryos.
2008,
Pubmed
Partida-Sánchez,
Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo.
2001,
Pubmed
Patel,
Acidic calcium stores open for business: expanding the potential for intracellular Ca2+ signaling.
2010,
Pubmed
Perraud,
ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology.
2001,
Pubmed
Ramakrishnan,
A single residue in a novel ADP-ribosyl cyclase controls production of the calcium-mobilizing messengers cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate.
2010,
Pubmed
,
Echinobase
Ramos,
Two-pore channels function in calcium regulation in sea star oocytes and embryos.
2014,
Pubmed
,
Echinobase
Saunders,
PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development.
2002,
Pubmed
Schmid,
Nicotinic acid adenine dinucleotide phosphate (NAADP) degradation by alkaline phosphatase.
2012,
Pubmed
Slusarski,
Calcium signaling in vertebrate embryonic patterning and morphogenesis.
2007,
Pubmed
Wallingford,
Calcium signaling during convergent extension in Xenopus.
2001,
Pubmed
Webb,
Ca2+ signaling and early embryonic patterning during the blastula and gastrula periods of zebrafish and Xenopus development.
2006,
Pubmed
Whitaker,
Calcium at fertilization and in early development.
2006,
Pubmed
Wilson,
Differential regulation of nicotinic acid-adenine dinucleotide phosphate and cADP-ribose production by cAMP and cGMP.
1998,
Pubmed
,
Echinobase
Zhao,
The membrane-bound enzyme CD38 exists in two opposing orientations.
2012,
Pubmed
