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Science 1993 Jul 16;2615119:348-52. doi: 10.1126/science.8392748.
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Redundant mechanisms of calcium-induced calcium release underlying calcium waves during fertilization of sea urchin eggs.

Galione A , McDougall A , Busa WB , Willmott N , Gillot I , Whitaker M .

Propagating Ca2+ waves are a characteristic feature of Ca(2+)-linked signal transduction pathways. Intracellular Ca2+ waves are formed by regenerative stimulation of Ca2+ release from intracellular stores by Ca2+ itself. Mechanisms that rely on either inositol trisphosphate or ryanodine receptor channels have been proposed to account for Ca2+ waves in various cell types. Both channel types contributed to the Ca2+ wave during fertilization of sea urchin eggs. Alternative mechanisms of Ca2+ release imply redundancy but may also allow for modulation and diversity in the generation of Ca2+ waves.

PubMed ID: 8392748
Article link: Science
Grant support: [+]

Genes referenced: LOC100887844 LOC115919080 LOC115919910