Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Development
2018 Dec 18;14524:. doi: 10.1242/dev.167288.
Show Gene links
Show Anatomy links
Conserved regulatory state expression controlled by divergent developmental gene regulatory networks in echinoids.
Erkenbrack EM
,
Davidson EH
,
Peter IS
.
???displayArticle.abstract???
Evolution of the animal body plan is driven by changes in developmental gene regulatory networks (GRNs), but how networks change to control novel developmental phenotypes remains, in most cases, unresolved. Here, we address GRN evolution by comparing the endomesoderm GRN in two echinoid sea urchins, Strongylocentrotus purpuratus and Eucidaris tribuloides, with at least 268 million years of independent evolution. We first analyzed the expression of twelve transcription factors and signaling molecules of the S. purpuratus GRN in E. tribuloides embryos, showing that orthologous regulatory genes are expressed in corresponding endomesodermal cell fates in the two species. However, perturbation of regulatory genes revealed that important regulatory circuits of the S. purpuratus GRN are significantly different in E. tribuloides For example, mesodermal Delta/Notch signaling controls exclusion of alternative cell fates in E. tribuloides but controls mesoderm induction and activation of a positive feedback circuit in S. purpuratus These results indicate that the architecture of the sea urchin endomesodermGRN evolved by extensive gain and loss of regulatory interactions between a conserved set of regulatory factors that control endomesodermal cell fate specification.
Arendt,
The origin and evolution of cell types.
2016, Pubmed
Arendt,
The origin and evolution of cell types.
2016,
Pubmed
Calestani,
Cis-regulatory analysis of the sea urchin pigment cell gene polyketide synthase.
2010,
Pubmed
,
Echinobase
Cameron,
Macromere cell fates during sea urchin development.
1991,
Pubmed
,
Echinobase
Cameron,
Cell type specification during sea urchin development.
1991,
Pubmed
,
Echinobase
Cameron,
Lineage and fate of each blastomere of the eight-cell sea urchin embryo.
1987,
Pubmed
,
Echinobase
Choe,
Genetic regulation of engrailed and wingless in Tribolium segmentation and the evolution of pair-rule segmentation.
2009,
Pubmed
Croce,
Dynamics of Delta/Notch signaling on endomesoderm segregation in the sea urchin embryo.
2010,
Pubmed
,
Echinobase
Cui,
Specific functions of the Wnt signaling system in gene regulatory networks throughout the early sea urchin embryo.
2014,
Pubmed
,
Echinobase
Cui,
Sequential Response to Multiple Developmental Network Circuits Encoded in an Intronic cis-Regulatory Module of Sea Urchin hox11/13b.
2017,
Pubmed
,
Echinobase
Damen,
Evolutionary conservation and divergence of the segmentation process in arthropods.
2007,
Pubmed
Davidson,
A provisional regulatory gene network for specification of endomesoderm in the sea urchin embryo.
2002,
Pubmed
,
Echinobase
Erkenbrack,
Evolutionary rewiring of gene regulatory network linkages at divergence of the echinoid subclasses.
2015,
Pubmed
,
Echinobase
Erkenbrack,
Divergence of ectodermal and mesodermal gene regulatory network linkages in early development of sea urchins.
2016,
Pubmed
,
Echinobase
Erwin,
The evolution of hierarchical gene regulatory networks.
2009,
Pubmed
Ettensohn,
Alx1, a member of the Cart1/Alx3/Alx4 subfamily of Paired-class homeodomain proteins, is an essential component of the gene network controlling skeletogenic fate specification in the sea urchin embryo.
2003,
Pubmed
,
Echinobase
Gao,
Transfer of a large gene regulatory apparatus to a new developmental address in echinoid evolution.
2008,
Pubmed
,
Echinobase
Gurdon,
A community effect in animal development.
1989,
Pubmed
Hinman,
Evolutionary plasticity of developmental gene regulatory network architecture.
2007,
Pubmed
,
Echinobase
Hinman,
Developmental gene regulatory network architecture across 500 million years of echinoderm evolution.
2003,
Pubmed
,
Echinobase
Hughes,
A novel role for gamma-secretase in the formation of primitive streak-like intermediates from ES cells in culture.
2009,
Pubmed
Li,
Encoding regulatory state boundaries in the pregastrular oral ectoderm of the sea urchin embryo.
2014,
Pubmed
,
Echinobase
Longabaugh,
Computational representation of developmental genetic regulatory networks.
2005,
Pubmed
Longabaugh,
BioTapestry: a tool to visualize the dynamic properties of gene regulatory networks.
2012,
Pubmed
Materna,
A comprehensive analysis of Delta signaling in pre-gastrular sea urchin embryos.
2012,
Pubmed
,
Echinobase
Materna,
Diversification of oral and aboral mesodermal regulatory states in pregastrular sea urchin embryos.
2013,
Pubmed
,
Echinobase
McCauley,
A conserved gene regulatory network subcircuit drives different developmental fates in the vegetal pole of highly divergent echinoderm embryos.
2010,
Pubmed
,
Echinobase
McCauley,
Expression of wnt and frizzled genes during early sea star development.
2013,
Pubmed
,
Echinobase
McCauley,
Development of an embryonic skeletogenic mesenchyme lineage in a sea cucumber reveals the trajectory of change for the evolution of novel structures in echinoderms.
2012,
Pubmed
,
Echinobase
McCauley,
Dose-dependent nuclear β-catenin response segregates endomesoderm along the sea star primary axis.
2015,
Pubmed
,
Echinobase
Narula,
Mathematical model of a gene regulatory network reconciles effects of genetic perturbations on hematopoietic stem cell emergence.
2013,
Pubmed
Ohguro,
Involvement of Delta and Nodal signals in the specification process of five types of secondary mesenchyme cells in embryo of the sea urchin, Hemicentrotus pulcherrimus.
2011,
Pubmed
,
Echinobase
Oliveri,
A regulatory gene network that directs micromere specification in the sea urchin embryo.
2002,
Pubmed
,
Echinobase
Oliveri,
Global regulatory logic for specification of an embryonic cell lineage.
2008,
Pubmed
,
Echinobase
Peel,
Arthropod segmentation: beyond the Drosophila paradigm.
2005,
Pubmed
Peter,
Regulatory states in the developmental control of gene expression.
2017,
Pubmed
,
Echinobase
Peter,
Assessing regulatory information in developmental gene regulatory networks.
2017,
Pubmed
,
Echinobase
Peter,
Predictive computation of genomic logic processing functions in embryonic development.
2012,
Pubmed
,
Echinobase
Peter,
The endoderm gene regulatory network in sea urchin embryos up to mid-blastula stage.
2010,
Pubmed
,
Echinobase
Peter,
Evolution of gene regulatory networks controlling body plan development.
2011,
Pubmed
Peter,
A gene regulatory network controlling the embryonic specification of endoderm.
2011,
Pubmed
,
Echinobase
Ransick,
Cis-regulatory logic driving glial cells missing: self-sustaining circuitry in later embryogenesis.
2012,
Pubmed
,
Echinobase
Ransick,
Late specification of Veg1 lineages to endodermal fate in the sea urchin embryo.
1998,
Pubmed
,
Echinobase
Ransick,
cis-regulatory processing of Notch signaling input to the sea urchin glial cells missing gene during mesoderm specification.
2006,
Pubmed
,
Echinobase
Royo,
Transphyletic conservation of developmental regulatory state in animal evolution.
2011,
Pubmed
,
Echinobase
Ruffins,
A fate map of the vegetal plate of the sea urchin (Lytechinus variegatus) mesenchyme blastula.
1996,
Pubmed
,
Echinobase
Sherwood,
LvNotch signaling mediates secondary mesenchyme specification in the sea urchin embryo.
1999,
Pubmed
,
Echinobase
Smith,
A spatially dynamic cohort of regulatory genes in the endomesodermal gene network of the sea urchin embryo.
2008,
Pubmed
,
Echinobase
Thompson,
Reorganization of sea urchin gene regulatory networks at least 268 million years ago as revealed by oldest fossil cidaroid echinoid.
2015,
Pubmed
,
Echinobase
Wray,
The origin of spicule-forming cells in a 'primitive' sea urchin (Eucidaris tribuloides) which appears to lack primary mesenchyme cells.
1988,
Pubmed
,
Echinobase
Yamazaki,
Larval mesenchyme cell specification in the primitive echinoid occurs independently of the double-negative gate.
2014,
Pubmed
,
Echinobase
Yamazaki,
Roles of hesC and gcm in echinoid larval mesenchyme cell development.
2016,
Pubmed
,
Echinobase
Zorn,
Vertebrate endoderm development and organ formation.
2009,
Pubmed
de-Leon,
Information processing at the foxa node of the sea urchin endomesoderm specification network.
2010,
Pubmed
,
Echinobase
