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Nat Commun 2015 Oct 01;6:8434. doi: 10.1038/ncomms9434.
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A deuterostome origin of the Spemann organiser suggested by Nodal and ADMPs functions in Echinoderms.

Lapraz F , Haillot E , Lepage T .

During development of chordates, establishment of the body plan relies on the activity of an organizing centre located on the dorsal side of the embryo that patterns the embryo and induces neural tissue. Intriguingly, the evolutionary origin of this crucial signalling centre remains unclear and whether analogous organizers regulate D/V patterning in other deuterostome or protostome phyla is not known. Here we provide evidence that the ventral ectoderm of the sea urchin embryo is a long-range organizing centre that shares several fundamental properties with the Spemann organizer: the ability to induce duplicated embryonic axes when ectopically induced, the ability to induce neural fate in neighbouring tissues and the ability to finely regulate the level of BMP signalling by using an autoregulatory expansion-repression mechanism. These findings suggest that the evolutionary origin of the Spemann organizer is more ancient than previously thought and that it may possibly be traced back to the common ancestor of deuterostomes.

PubMed ID: 26423516
PMC ID: PMC4600745
Article link: Nat Commun

Species referenced: Echinodermata
Genes referenced: bmp2 bmpr1b chrd foxa1 foxg1 gcml hoxal irx4 lefty1 LOC100887844 LOC100889251 LOC100892350 LOC105438994 LOC115919910 LOC575170 LOC578116 LOC578814 LOC583082 LOC587197 LOC590282 LOC590297 LOC593908 LOC764641 msx1 nodall onecut2 pax2 pax2l pole stk36 tbx2 univin
Antibodies: phospho-smad1 Ab1

Article Images: [+] show captions
References [+] :
Agius, Endodermal Nodal-related signals and mesoderm induction in Xenopus. 2000, Pubmed