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ECB-ART-49082
Cells Dev 2021 Sep 01;167:203716. doi: 10.1016/j.cdev.2021.203716.
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Conditional specification of endomesoderm.

McClay DR , Croce JC , Warner JF .


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Early in animal development many cells are conditionally specified based on observations that those cells can be directed toward alternate fates. The endomesoderm is so named because early specification produces cells that often have been observed to simultaneously express both early endoderm and mesoderm transcription factors. Experiments with these cells demonstrate that their progeny can directed entirely toward endoderm or mesoderm, whereas normally they establish both germ layers. This review examines the mechanisms that initiate the conditional endomesoderm state, its metastability, and the mechanisms that resolve that state into definitive endoderm and mesoderm.

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References [+] :
Acloque, Reciprocal repression between Sox3 and snail transcription factors defines embryonic territories at gastrulation. 2011, Pubmed