ECB-ART-42966
Mol Reprod Dev
2014 Aug 01;818:679-711. doi: 10.1002/mrd.22223.
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The biology of the germ line in echinoderms.
Wessel GM
,
Brayboy L
,
Fresques T
,
Gustafson EA
,
Oulhen N
,
Ramos I
,
Reich A
,
Swartz SZ
,
Yajima M
,
Zazueta V
.
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The formation of the germ line in an embryo marks a fresh round of reproductive potential. The developmental stage and location within the embryo where the primordial germ cells (PGCs) form, however, differs markedly among species. In many animals, the germ line is formed by an inherited mechanism, in which molecules made and selectively partitioned within the oocyte drive the early development of cells that acquire this material to a germ-line fate. In contrast, the germ line of other animals is fated by an inductive mechanism that involves signaling between cells that directs this specialized fate. In this review, we explore the mechanisms of germ-line determination in echinoderms, an early-branching sister group to the chordates. One member of the phylum, sea urchins, appears to use an inherited mechanism of germ-line formation, whereas their relatives, the sea stars, appear to use an inductive mechanism. We first integrate the experimental results currently available for germ-line determination in the sea urchin, for which considerable new information is available, and then broaden the investigation to the lesser-known mechanisms in sea stars and other echinoderms. Even with this limited insight, it appears that sea stars, and perhaps the majority of the echinoderm taxon, rely on inductive mechanisms for germ-line fate determination. This enables a strongly contrasted picture for germ-line determination in this phylum, but one for which transitions between different modes of germ-line determination might now be experimentally addressed.
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Genes referenced: LOC100887844
References [+] :
Amit,
Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway.
2002, Pubmed
Amit, Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway. 2002, Pubmed
Ancelin, Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells. 2006, Pubmed
Anderson, RNA granules. 2006, Pubmed
Andrews, Multiple mechanisms collaborate to repress nanos translation in the Drosophila ovary and embryo. 2011, Pubmed
Angerer, SoxB1 downregulation in vegetal lineages of sea urchin embryos is achieved by both transcriptional repression and selective protein turnover. 2005, Pubmed , Echinobase
Angerer, Animal-vegetal axis patterning mechanisms in the early sea urchin embryo. 2000, Pubmed , Echinobase
Balser, Ultrastructure of the Coeloms of Auricularia Larvae (Holothuroidea: Echinodermata): Evidence for the Presence of an Axocoel. 1993, Pubmed , Echinobase
Batchelder, Transcriptional repression by the Caenorhabditis elegans germ-line protein PIE-1. 1999, Pubmed
Becalska, Lighting up mRNA localization in Drosophila oogenesis. 2009, Pubmed
Becalska, Aubergine is a component of a nanos mRNA localization complex. 2011, Pubmed
Bennett, Larval development and metamorphosis of the deep-sea cidaroid urchin Cidaris blakei. 2012, Pubmed , Echinobase
Bessodes, Reciprocal signaling between the ectoderm and a mesendodermal left-right organizer directs left-right determination in the sea urchin embryo. 2012, Pubmed , Echinobase
Betschinger, Dare to be different: asymmetric cell division in Drosophila, C. elegans and vertebrates. 2004, Pubmed
Bialecka, Cdx2 contributes to the expansion of the early primordial germ cell population in the mouse. 2012, Pubmed
Breitwieser, Oskar protein interaction with Vasa represents an essential step in polar granule assembly. 1996, Pubmed
Buehr, Sterility and partial sterility in the South African clawed toad following the pricking of the egg. 1970, Pubmed
Bunting, Enforced P-glycoprotein pump function in murine bone marrow cells results in expansion of side population stem cells in vitro and repopulating cells in vivo. 2000, Pubmed
Bunting, ABC transporters as phenotypic markers and functional regulators of stem cells. 2002, Pubmed
Bushati, Temporal reciprocity of miRNAs and their targets during the maternal-to-zygotic transition in Drosophila. 2008, Pubmed
Cameron, Macromere cell fates during sea urchin development. 1991, Pubmed , Echinobase
Cameron, Lineage and fate of each blastomere of the eight-cell sea urchin embryo. 1987, Pubmed , Echinobase
Campanale, Programmed reduction of ABC transporter activity in sea urchin germline progenitors. 2012, Pubmed , Echinobase
Campo-Paysaa, microRNA complements in deuterostomes: origin and evolution of microRNAs. 2011, Pubmed , Echinobase
Carafoli, Generation, control, and processing of cellular calcium signals. 2001, Pubmed
Chen, Deciphering arginine methylation: Tudor tells the tale. 2011, Pubmed
Chong, Molecular markers to characterize the hermaphroditic reproductive system of the planarian Schmidtea mediterranea. 2011, Pubmed
Croce, The canonical Wnt pathway in embryonic axis polarity. 2006, Pubmed , Echinobase
Dale, Polarized distribution of L-type calcium channels in early sea urchin embryos. 1997, Pubmed , Echinobase
Davidson, Gene regulatory networks and the evolution of animal body plans. 2006, Pubmed
Davidson, Emerging properties of animal gene regulatory networks. 2010, Pubmed
DeRenzo, Exclusion of germ plasm proteins from somatic lineages by cullin-dependent degradation. 2003, Pubmed
DeRenzo, A clean start: degradation of maternal proteins at the oocyte-to-embryo transition. 2004, Pubmed
Dean, The human ATP-binding cassette (ABC) transporter superfamily. 2001, Pubmed
Deeley, Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. 2006, Pubmed
Duboc, Left-right asymmetry in the sea urchin embryo is regulated by nodal signaling on the right side. 2005, Pubmed , Echinobase
Eddy, Germ plasm and the differentiation of the germ cell line. 1975, Pubmed
Emily-Fenouil, GSK3beta/shaggy mediates patterning along the animal-vegetal axis of the sea urchin embryo. 1998, Pubmed , Echinobase
Erwin, The Cambrian conundrum: early divergence and later ecological success in the early history of animals. 2011, Pubmed
Ettensohn, The emergence of pattern in embryogenesis: regulation of beta-catenin localization during early sea urchin development. 2006, Pubmed , Echinobase
Ettensohn, Lessons from a gene regulatory network: echinoderm skeletogenesis provides insights into evolution, plasticity and morphogenesis. 2009, Pubmed , Echinobase
Ettensohn, Cell lineage conversion in the sea urchin embryo. 1988, Pubmed , Echinobase
Ettensohn, The invertebrate deuterostomes: an introduction to their phylogeny, reproduction, development, and genomics. 2004, Pubmed
Extavour, Mechanisms of germ cell specification across the metazoans: epigenesis and preformation. 2003, Pubmed
Fink, Three cell recognition changes accompany the ingression of sea urchin primary mesenchyme cells. 1985, Pubmed , Echinobase
Frohnhöfer, Manipulating the anteroposterior pattern of the Drosophila embryo. 1986, Pubmed
Fujii, Role of the nanos homolog during sea urchin development. 2009, Pubmed , Echinobase
Gao, Next generation organelles: structure and role of germ granules in the germline. 2013, Pubmed
Garneau, The highways and byways of mRNA decay. 2007, Pubmed
Gavis, Identification of cis-acting sequences that control nanos RNA localization. 1996, Pubmed
Ghosh, Inhibition of transcription by the Caenorhabditis elegans germline protein PIE-1: genetic evidence for distinct mechanisms targeting initiation and elongation. 2008, Pubmed
Giraldez, Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs. 2006, Pubmed
Groigno, An anaphase calcium signal controls chromosome disjunction in early sea urchin embryos. 1998, Pubmed , Echinobase
Guo, par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed. 1995, Pubmed
Gustafson, DEAD-box helicases: posttranslational regulation and function. 2010, Pubmed
Gustafson, Vasa genes: emerging roles in the germ line and in multipotent cells. 2010, Pubmed
Gustafson, Exogenous RNA is selectively retained in the small micromeres during sea urchin embryogenesis. 2010, Pubmed , Echinobase
Gustafson, Post-translational regulation by gustavus contributes to selective Vasa protein accumulation in multipotent cells during embryogenesis. 2011, Pubmed , Echinobase
Gökirmak, Localization and substrate selectivity of sea urchin multidrug (MDR) efflux transporters. 2012, Pubmed , Echinobase
HORSTADIUS, The mechanics of sea urchin development. 1950, Pubmed , Echinobase
Haenisch, Influence of genetic polymorphisms on intestinal expression and rifampicin-type induction of ABCC2 and on bioavailability of talinolol. 2008, Pubmed
Haenisch, Down-regulation of ATP-binding cassette C2 protein expression in HepG2 cells after rifampicin treatment is mediated by microRNA-379. 2011, Pubmed
Hamdoun, Activation of multidrug efflux transporter activity at fertilization in sea urchin embryos (Strongylocentrotus purpuratus). 2004, Pubmed , Echinobase
Hanyu-Nakamura, Drosophila Pgc protein inhibits P-TEFb recruitment to chromatin in primordial germ cells. 2008, Pubmed
Hay, Localization of vasa, a component of Drosophila polar granules, in maternal-effect mutants that alter embryonic anteroposterior polarity. 1990, Pubmed
Higgins, Binding protein-dependent transport systems. 1990, Pubmed
Hinman, Developmental gene regulatory network architecture across 500 million years of echinoderm evolution. 2003, Pubmed , Echinobase
Holy, Differential behavior of centrosomes in unequally dividing blastomeres during fourth cleavage of sea urchin embryos. 1991, Pubmed , Echinobase
Hsu, Yeast cells lacking 5'-->3' exoribonuclease 1 contain mRNA species that are poly(A) deficient and partially lack the 5' cap structure. 1993, Pubmed
Illmensee, Transplantation of posterior polar plasm in Drosophila. Induction of germ cells at the anterior pole of the egg. 1974, Pubmed
Janies, Echinoderm phylogeny including Xyloplax, a progenetic asteroid. 2011, Pubmed , Echinobase
Jazdowska-Zagrodzińska, Experimental studies on the role of 'polar granules' in the segregation of pole cells in Drosophila melanogaster. 1966, Pubmed
Johnson, Evolution of the germ line-soma relationship in vertebrate embryos. 2011, Pubmed
Juliano, Germ line determinants are not localized early in sea urchin development, but do accumulate in the small micromere lineage. 2006, Pubmed , Echinobase
Juliano, An evolutionary transition of Vasa regulation in echinoderms. 2009, Pubmed , Echinobase
Juliano, Nanos functions to maintain the fate of the small micromere lineage in the sea urchin embryo. 2010, Pubmed , Echinobase
Juliano, Developmental biology. Versatile germline genes. 2010, Pubmed
Kadri, RNA deep sequencing reveals differential microRNA expression during development of sea urchin and sea star. 2011, Pubmed , Echinobase
Kassmer, Very small embryonic-like cells: biology and function of these potential endogenous pluripotent stem cells in adult tissues. 2013, Pubmed
Kedde, RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. 2007, Pubmed
Kiehart, Evidence that myosin does not contribute to force production in chromosome movement. 1982, Pubmed , Echinobase
Knaut, Zebrafish vasa RNA but not its protein is a component of the germ plasm and segregates asymmetrically before germline specification. 2000, Pubmed
Koga, Functional evolution of Ets in echinoderms with focus on the evolution of echinoderm larval skeletons. 2010, Pubmed , Echinobase
Krueger, LET-99 inhibits lateral posterior pulling forces during asymmetric spindle elongation in C. elegans embryos. 2010, Pubmed
Kugler, Regulation of Drosophila vasa in vivo through paralogous cullin-RING E3 ligase specificity receptors. 2010, Pubmed
Kumburegama, Wnt signaling in the early sea urchin embryo. 2008, Pubmed , Echinobase
Kuraishi, Structural and functional polarity of starfish blastomeres. 1989, Pubmed , Echinobase
Kuraishi, Cell Movements during Gastrulation of Starfish Larvae. 1992, Pubmed , Echinobase
Kurihara, Developmental potential of small micromeres in sea urchin embryos. 2005, Pubmed , Echinobase
Köprunner, A zebrafish nanos-related gene is essential for the development of primordial germ cells. 2001, Pubmed
Kühl, Ca(2+)/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus. 2000, Pubmed
Kühl, The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape. 2000, Pubmed
Lai, Repressive translational control in germ cells. 2013, Pubmed
Larimer, Characterization of the XRN1 gene encoding a 5'-->3' exoribonuclease: sequence data and analysis of disparate protein and mRNA levels of gene-disrupted yeast cells. 1992, Pubmed
Lasko, Posttranscriptional regulation in Drosophila oocytes and early embryos. 2011, Pubmed
Lasko, The DEAD-box helicase Vasa: evidence for a multiplicity of functions in RNA processes and developmental biology. 2013, Pubmed , Echinobase
Lasko, Posterior localization of vasa protein correlates with, but is not sufficient for, pole cell development. 1990, Pubmed
Lasko, The product of the Drosophila gene vasa is very similar to eukaryotic initiation factor-4A. 1988, Pubmed
Lee, Molecular phylogenies and divergence times of sea urchin species of Strongylocentrotidae, Echinoida. 2003, Pubmed , Echinobase
Leonard, Analysis of dishevelled localization and function in the early sea urchin embryo. 2007, Pubmed , Echinobase
Lesch, Genetics of germ cell development. 2012, Pubmed
Li, Cloning and characterization of the SSB-1 and SSB-4 genes expressed in zebrafish gonads. 2009, Pubmed
Liu, Fat facets interacts with vasa in the Drosophila pole plasm and protects it from degradation. 2003, Pubmed
Liu, Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain. 2010, Pubmed
Livi, Expression and function of blimp1/krox, an alternatively transcribed regulatory gene of the sea urchin endomesoderm network. 2006, Pubmed , Echinobase
Logan, The Wnt signaling pathway in development and disease. 2004, Pubmed
Logan, Nuclear beta-catenin is required to specify vegetal cell fates in the sea urchin embryo. 1999, Pubmed , Echinobase
Luo, Opposing nodal and BMP signals regulate left-right asymmetry in the sea urchin larva. 2012, Pubmed , Echinobase
Lykke-Andersen, The eukaryotic RNA exosome: same scaffold but variable catalytic subunits. 2011, Pubmed
Mahowald, Assembly of the Drosophila germ plasm. 2001, Pubmed
Mallatt, Ribosomal RNA genes and deuterostome phylogeny revisited: more cyclostomes, elasmobranchs, reptiles, and a brittle star. 2007, Pubmed , Echinobase
Mani, Untangling the web: the diverse functions of the PIWI/piRNA pathway. 2013, Pubmed
Martinho, A noncoding RNA is required for the repression of RNApolII-dependent transcription in primordial germ cells. 2004, Pubmed
Materna, Notch and Nodal control forkhead factor expression in the specification of multipotent progenitors in sea urchin. 2013, Pubmed , Echinobase
Mathioudakis, The multiple Tudor domain-containing protein TDRD1 is a molecular scaffold for mouse Piwi proteins and piRNA biogenesis factors. 2012, Pubmed
McCauley, Development of an embryonic skeletogenic mesenchyme lineage in a sea cucumber reveals the trajectory of change for the evolution of novel structures in echinoderms. 2012, Pubmed , Echinobase
McClay, Specification of endoderm and mesoderm in the sea urchin. 2000, Pubmed , Echinobase
McClay, Evolutionary crossroads in developmental biology: sea urchins. 2011, Pubmed , Echinobase
Mello, The PIE-1 protein and germline specification in C. elegans embryos. 1996, Pubmed
Minokawa, Timing of the potential of micromere-descendants in echinoid embryos to induce endoderm differentiation of mesomere-descendants. 1999, Pubmed , Echinobase
Minokawa, cis-Regulatory inputs of the wnt8 gene in the sea urchin endomesoderm network. 2005, Pubmed , Echinobase
Mishima, Differential regulation of germline mRNAs in soma and germ cells by zebrafish miR-430. 2006, Pubmed
Morin, Mitotic spindle orientation in asymmetric and symmetric cell divisions during animal development. 2011, Pubmed
Morris, Development of the five primary podia from the coeloms of a sea star larva: homology with the echinoid echinoderms and other deuterostomes. 2009, Pubmed , Echinobase
Nagamori, Regulation of an RNA granule during spermatogenesis: acetylation of MVH in the chromatoid body of germ cells. 2011, Pubmed
Nakamura, Less is more: specification of the germline by transcriptional repression. 2008, Pubmed
Nakano, Larval stages of a living sea lily (stalked crinoid echinoderm). 2003, Pubmed , Echinobase
Ohinata, Blimp1 is a critical determinant of the germ cell lineage in mice. 2005, Pubmed
Okada, Restoration of fertility in sterilized Drosophila eggs by transplantation of polar cytoplasm. 1974, Pubmed
Okanishi, Molecular phylogeny of the order Euryalida (Echinodermata: Ophiuroidea), based on mitochondrial and nuclear ribosomal genes. 2011, Pubmed , Echinobase
Oliveri, Gene regulatory network controlling embryonic specification in the sea urchin. 2004, Pubmed , Echinobase
Oliveri, A regulatory gene network that directs micromere specification in the sea urchin embryo. 2002, Pubmed , Echinobase
Orsborn, GLH-1, the C. elegans P granule protein, is controlled by the JNK KGB-1 and by the COP9 subunit CSN-5. 2007, Pubmed
Otsuka, Approaches for studying PMR1 endonuclease-mediated mRNA decay. 2008, Pubmed
Oulhen, Retention of exogenous mRNAs selectively in the germ cells of the sea urchin requires only a 5'-cap and a 3'-UTR. 2013, Pubmed , Echinobase
Oulhen, The 3'UTR of nanos2 directs enrichment in the germ cell lineage of the sea urchin. 2013, Pubmed , Echinobase
Park, Dynamic localization of LIN-5 and GPR-1/2 to cortical force generation domains during spindle positioning. 2008, Pubmed
Pehrson, The fate of the small micromeres in sea urchin development. 1986, Pubmed , Echinobase
Perseke, The impact of mitochondrial genome analyses on the understanding of deuterostome phylogeny. 2013, Pubmed , Echinobase
Peter, Evolution of gene regulatory networks controlling body plan development. 2011, Pubmed
Peterson, Set-aside cells in maximal indirect development: evolutionary and developmental significance. 1997, Pubmed
Rafiq, The genomic regulatory control of skeletal morphogenesis in the sea urchin. 2012, Pubmed , Echinobase
Ransick, New early zygotic regulators expressed in endomesoderm of sea urchin embryos discovered by differential array hybridization. 2002, Pubmed , Echinobase
Ransick, Micromeres are required for normal vegetal plate specification in sea urchin embryos. 1995, Pubmed , Echinobase
Ransick, A complete second gut induced by transplanted micromeres in the sea urchin embryo. 1993, Pubmed , Echinobase
Ransick, Postembryonic segregation of the germ line in sea urchins in relation to indirect development. 1996, Pubmed , Echinobase
Raz, The function and regulation of vasa-like genes in germ-cell development. 2000, Pubmed
Reese, Asymmetric segregation of PIE-1 in C. elegans is mediated by two complementary mechanisms that act through separate PIE-1 protein domains. 2000, Pubmed
Ricardo, An ABC transporter controls export of a Drosophila germ cell attractant. 2009, Pubmed
Rodriguez, Seawi--a sea urchin piwi/argonaute family member is a component of MT-RNP complexes. 2005, Pubmed , Echinobase
Rongo, Regulated synthesis, transport and assembly of the Drosophila germ plasm. 1996, Pubmed
Rouget, Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo. 2010, Pubmed
Rouhana, PRMT5 and the role of symmetrical dimethylarginine in chromatoid bodies of planarian stem cells. 2012, Pubmed
Rudolph, Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3. 2007, Pubmed
Salinas, The DEAD box RNA helicase VBH-1 is required for germ cell function in C. elegans. 2007, Pubmed
Sarkadi, Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system. 2006, Pubmed
Schaefer, A protein complex containing Inscuteable and the Galpha-binding protein Pins orients asymmetric cell divisions in Drosophila. 2000, Pubmed
Schaner, A conserved chromatin architecture marks and maintains the restricted germ cell lineage in worms and flies. 2003, Pubmed
Scherer, The finished DNA sequence of human chromosome 12. 2006, Pubmed
Schmid, The exosome: a multipurpose RNA-decay machine. 2008, Pubmed
Schubert, MEX-5 and MEX-6 function to establish soma/germline asymmetry in early C. elegans embryos. 2000, Pubmed
Seervai, Lessons for inductive germline determination. 2013, Pubmed
Seki, Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in mice. 2007, Pubmed
Selbach, Widespread changes in protein synthesis induced by microRNAs. 2008, Pubmed
Seydoux, Pathway to totipotency: lessons from germ cells. 2006, Pubmed
Seydoux, Transcriptionally repressed germ cells lack a subpopulation of phosphorylated RNA polymerase II in early embryos of Caenorhabditis elegans and Drosophila melanogaster. 1997, Pubmed
Sheldahl, Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos. 2003, Pubmed
Sherwood, LvNotch signaling mediates secondary mesenchyme specification in the sea urchin embryo. 1999, Pubmed , Echinobase
Shipp, ATP-binding cassette (ABC) transporter expression and localization in sea urchin development. 2012, Pubmed , Echinobase
Shirae-Kurabayashi, Ci-Pem-1 localizes to the nucleus and represses somatic gene transcription in the germline of Ciona intestinalis embryos. 2011, Pubmed
Shuster, Transitions regulating the timing of cytokinesis in embryonic cells. 2002, Pubmed , Echinobase
Smith, The oldest echinoderm faunas from Gondwana show that echinoderm body plan diversification was rapid. 2013, Pubmed , Echinobase
Smith, The role of a "germinal plasm" in the formation of primordial germ cells in Rana pipiens. 1966, Pubmed
Smith, Testing the molecular clock: molecular and paleontological estimates of divergence times in the Echinoidea (Echinodermata). 2006, Pubmed , Echinobase
Sodergren, The genome of the sea urchin Strongylocentrotus purpuratus. 2006, Pubmed , Echinobase
Song, Select microRNAs are essential for early development in the sea urchin. 2012, Pubmed , Echinobase
Song, The forkhead transcription factor FoxY regulates Nanos. 2012, Pubmed , Echinobase
Styhler, VASA localization requires the SPRY-domain and SOCS-box containing protein, GUSTAVUS. 2002, Pubmed
Sugioka, Wnt regulates spindle asymmetry to generate asymmetric nuclear β-catenin in C. elegans. 2011, Pubmed
Surani, Germ line, stem cells, and epigenetic reprogramming. 2008, Pubmed
Tanaka, The mouse homolog of Drosophila Vasa is required for the development of male germ cells. 2000, Pubmed
Terasaki, Organization of the sea urchin egg endoplasmic reticulum and its reorganization at fertilization. 1991, Pubmed , Echinobase
Tomancak, Oocyte polarity depends on regulation of gurken by Vasa. 1998, Pubmed
Tominaga, Reproduction and development of the conspicuously dimorphic brittle star Ophiodaphne formata (Ophiuroidea). 2004, Pubmed , Echinobase
Török, Imaging the spatial dynamics of calmodulin activation during mitosis. 1998, Pubmed , Echinobase
Vellutini, Embryonic, larval, and juvenile development of the sea biscuit Clypeaster subdepressus (Echinodermata: Clypeasteroida). 2010, Pubmed , Echinobase
Vonica, TCF is the nuclear effector of the beta-catenin signal that patterns the sea urchin animal-vegetal axis. 2000, Pubmed , Echinobase
Voronina, Activator of G-protein signaling in asymmetric cell divisions of the sea urchin embryo. 2006, Pubmed , Echinobase
Voronina, Vasa protein expression is restricted to the small micromeres of the sea urchin, but is inducible in other lineages early in development. 2008, Pubmed , Echinobase
Voronina, The diverse functions of germline P-granules in Caenorhabditis elegans. 2013, Pubmed
Warn, Restroation of the capacity to form pole cells in u.v.-irradiated Drosophila embryos. 1975, Pubmed
Whitaker, Calcium at fertilization and in early development. 2006, Pubmed
Wiederhold, Cytoplasmic deadenylation: regulation of mRNA fate. 2010, Pubmed
Wikramanayake, beta-Catenin is essential for patterning the maternally specified animal-vegetal axis in the sea urchin embryo. 1998, Pubmed , Echinobase
Wilding, Activation-dependent and activation-independent localisation of calmodulin to the mitotic apparatus during the first cell cycle of the Lytechinus pictus embryo. 1995, Pubmed , Echinobase
Wolke, Multiple levels of posttranscriptional control lead to germ line-specific gene expression in the zebrafish. 2002, Pubmed
Wray, The origin of spicule-forming cells in a 'primitive' sea urchin (Eucidaris tribuloides) which appears to lack primary mesenchyme cells. 1988, Pubmed , Echinobase
Xiao, EENdb: a database and knowledge base of ZFNs and TALENs for endonuclease engineering. 2013, Pubmed
Xing, Murine homologues of the Drosophila gustavus gene are expressed in ovarian granulosa cells. 2006, Pubmed
Yabe, Multidrug resistance-associated protein MRP-1 regulates dauer diapause by its export activity in Caenorhabditis elegans. 2005, Pubmed
Yajima, Small micromeres contribute to the germline in the sea urchin. 2011, Pubmed , Echinobase
Yajima, Autonomy in specification of primordial germ cells and their passive translocation in the sea urchin. 2012, Pubmed , Echinobase
Yamashita, Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome. 2003, Pubmed
Yazaki, Functional gap junctions in the early sea urchin embryo are localized to the vegetal pole. 1999, Pubmed , Echinobase
Yazaki, Mechanisms of calcium elevation in the micromeres of sea urchin embryos. 2004, Pubmed , Echinobase
Yazaki, Ca(2+) in specification of vegetal cell fate in early sea urchin embryos. 2001, Pubmed , Echinobase
Yoon, Zebrafish vasa homologue RNA is localized to the cleavage planes of 2- and 4-cell-stage embryos and is expressed in the primordial germ cells. 1997, Pubmed
Yoshigaki, Simulation of the mechanism of determining the position of the cleavage furrow in cytokinesis of sea urchin eggs. 2001, Pubmed , Echinobase
Zhang, A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb. 2003, Pubmed
Zhou, The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. 2001, Pubmed