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Mar Drugs
2015 Mar 06;133:1202-23. doi: 10.3390/md13031202.
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Anticancer activity of sea cucumber triterpene glycosides.
Aminin DL
,
Menchinskaya ES
,
Pisliagin EA
,
Silchenko AS
,
Avilov SA
,
Kalinin VI
.
Abstract
Triterpene glycosides are characteristic secondary metabolites of sea cucumbers (Holothurioidea, Echinodermata). They have hemolytic, cytotoxic, antifungal, and other biological activities caused by membranotropic action. These natural products suppress the proliferation of various human tumor cell lines in vitro and, more importantly, intraperitoneal administration in rodents of solutions of some sea cucumber triterpene glycosides significantly reduces both tumor burden and metastasis. The anticancer molecular mechanisms include the induction of tumor cell apoptosis through the activation of intracellular caspase cell death pathways, arrest of the cell cycle at S or G2/M phases, influence on nuclear factors, NF-κB, and up-down regulation of certain cellular receptors and enzymes participating in cancerogenesis, such as EGFR (epidermal growth factor receptor), Akt (protein kinase B), ERK (extracellular signal-regulated kinases), FAK (focal adhesion kinase), MMP-9 (matrix metalloproteinase-9) and others. Administration of some glycosides leads to a reduction of cancer cell adhesion, suppression of cell migration and tube formation in those cells, suppression of angiogenesis, inhibition of cell proliferation, colony formation and tumor invasion. As a result, marked growth inhibition of tumors occurs in vitro and in vivo. Some holothurian triterpene glycosides have the potential to be used as P-gp mediated MDR reversal agents in combined therapy with standard cytostatics.
Al Marzouqi,
Frondoside A inhibits human breast cancer cell survival, migration, invasion and the growth of breast tumor xenografts.
2011, Pubmed,
Echinobase
Al Marzouqi,
Frondoside A inhibits human breast cancer cell survival, migration, invasion and the growth of breast tumor xenografts.
2011,
Pubmed
,
Echinobase
Al Shemaili,
Frondoside A enhances the antiproliferative effects of gemcitabine in pancreatic cancer.
2014,
Pubmed
,
Echinobase
Aminin,
Antitumor activity of the immunomodulatory lead Cumaside.
2010,
Pubmed
,
Echinobase
Attoub,
Frondoside a suppressive effects on lung cancer survival, tumor growth, angiogenesis, invasion, and metastasis.
2013,
Pubmed
,
Echinobase
Avilov,
Synaptosides A and A1, triterpene glycosides from the sea cucumber Synapta maculata containing 3-O-methylglucuronic acid and their cytotoxic activity against tumor cells.
2008,
Pubmed
,
Echinobase
Bordbar,
High-value components and bioactives from sea cucumbers for functional foods--a review.
2011,
Pubmed
,
Echinobase
Careaga,
Antiproliferative, cytotoxic and hemolytic activities of a triterpene glycoside from Psolus patagonicus and its desulfated analog.
2009,
Pubmed
,
Echinobase
FRIESS,
Some pharmacologic properties of holothurin A, a glycosidic mixture from the sea cucumber.
1960,
Pubmed
,
Echinobase
Fan,
[Studies on the purification of water-soluble holothurian glycosides from Apostichopus japonicus and their tumor suppressing activity].
2009,
Pubmed
,
Echinobase
Flammang,
Biomechanics of adhesion in sea cucumber cuvierian tubules (echinodermata, holothuroidea).
2002,
Pubmed
,
Echinobase
Han,
Cytotoxic holostane-type triterpene glycosides from the sea cucumber Pentacta quadrangularis.
2010,
Pubmed
,
Echinobase
Janakiram,
Chemopreventive effects of Frondanol A5, a Cucumaria frondosa extract, against rat colon carcinogenesis and inhibition of human colon cancer cell growth.
2010,
Pubmed
,
Echinobase
Jin,
Differential effects of triterpene glycosides, frondoside A and cucumarioside A2-2 isolated from sea cucumbers on caspase activation and apoptosis of human leukemia cells.
2009,
Pubmed
,
Echinobase
Kim,
Triterpene glycosides from sea cucumbers and their biological activities.
2012,
Pubmed
,
Echinobase
Kovalchuk,
Estrogenic activity of triterpene glycosides in yeast two-hybrid assay.
2006,
Pubmed
,
Echinobase
Li,
Echinoside A, a new marine-derived anticancer saponin, targets topoisomerase2alpha by unique interference with its DNA binding and catalytic cycle.
2010,
Pubmed
,
Echinobase
Li,
Review of the apoptosis pathways in pancreatic cancer and the anti-apoptotic effects of the novel sea cucumber compound, Frondoside A.
2008,
Pubmed
,
Echinobase
Liu,
Argusides D and E, two new cytotoxic triterpene glycosides from the sea cucumber Bohadschia argus Jaeger.
2008,
Pubmed
,
Echinobase
Ma,
Frondoside A inhibits breast cancer metastasis and antagonizes prostaglandin E receptors EP4 and EP2.
2012,
Pubmed
,
Echinobase
Menchinskaya,
Inhibition of tumor cells multidrug resistance by cucumarioside A2-2, frondoside A and their complexes with cholesterol.
2013,
Pubmed
,
Echinobase
Menchinskaya,
Antitumor activity of cucumarioside A2-2.
2013,
Pubmed
,
Echinobase
Nigrelli,
Substances of potential biomedical importance from marine organisms.
1967,
Pubmed
Osbourn,
The saponins: polar isoprenoids with important and diverse biological activities.
2011,
Pubmed
,
Echinobase
Park,
Relationships between chemical structures and functions of triterpene glycosides isolated from sea cucumbers.
2014,
Pubmed
,
Echinobase
Park,
Frondoside A has an anti-invasive effect by inhibiting TPA-induced MMP-9 activation via NF-κB and AP-1 signaling in human breast cancer cells.
2012,
Pubmed
Podolak,
Saponins as cytotoxic agents: a review.
2010,
Pubmed
Roginsky,
Anti-pancreatic cancer effects of a polar extract from the edible sea cucumber, Cucumaria frondosa.
2010,
Pubmed
,
Echinobase
Silchenko,
Constituents of the sea cucumber Cucumaria okhotensis. Structures of okhotosides B1-B3 and cytotoxic activities of some glycosides from this species.
2008,
Pubmed
,
Echinobase
Sun,
A new cytotoxic lanostane-type triterpene glycoside from the sea cucumber Holothuria impatiens.
2007,
Pubmed
,
Echinobase
Tian,
Philinopside E, a new sulfated saponin from sea cucumber, blocks the interaction between kinase insert domain-containing receptor (KDR) and alphavbeta3 integrin via binding to the extracellular domain of KDR.
2007,
Pubmed
,
Echinobase
Tian,
PE, a new sulfated saponin from sea cucumber, exhibits anti-angiogenic and anti-tumor activities in vitro and in vivo.
2005,
Pubmed
,
Echinobase
Tong,
Philinopside A, a novel marine-derived compound possessing dual anti-angiogenic and anti-tumor effects.
2005,
Pubmed
,
Echinobase
Van Dyck,
Qualitative and quantitative saponin contents in five sea cucumbers from the Indian ocean.
2010,
Pubmed
,
Echinobase
Van Dyck,
The triterpene glycosides of Holothuria forskali: usefulness and efficiency as a chemical defense mechanism against predatory fish.
2011,
Pubmed
,
Echinobase
Wu,
Hillasides A and B, two new cytotoxic triterpene glycosides from the sea cucumber Holothuria hilla Lesson.
2007,
Pubmed
,
Echinobase
Yun,
Stichoposide C induces apoptosis through the generation of ceramide in leukemia and colorectal cancer cells and shows in vivo antitumor activity.
2012,
Pubmed
,
Echinobase
Zhang,
Philinopsides E and F, two new sulfated triterpene glycosides from the sea cucumber Pentacta quadrangularis.
2006,
Pubmed
,
Echinobase
Zhang,
[Studies on antitumor activities of triterpene glycoside colochiroside A from sea cucumber Colochirus anceps].
2011,
Pubmed
,
Echinobase
Zhang,
Cytotoxic triterpene glycosides from the sea cucumber Pseudocolochirus violaceus.
2007,
Pubmed
,
Echinobase
Zhao,
Ds-echinoside A, a new triterpene glycoside derived from sea cucumber, exhibits antimetastatic activity via the inhibition of NF-κB-dependent MMP-9 and VEGF expressions.
2011,
Pubmed
,
Echinobase
Zhao,
In vitro and in vivo anti-tumour activities of echinoside A and ds-echinoside A from Pearsonothuria graeffei.
2012,
Pubmed
,
Echinobase
Zhao,
Differential effects of sulfated triterpene glycosides, holothurin A1, and 24-dehydroechinoside A, on antimetastasic activity via regulation of the MMP-9 signal pathway.
2010,
Pubmed
,
Echinobase
Zou,
Intercedensides A-C, three new cytotoxic triterpene glycosides from the sea cucumber Mensamaria intercedens Lampert.
2003,
Pubmed
,
Echinobase