ECB-ART-43584
Mol Reprod Dev
2014 Sep 01;819:778-93. doi: 10.1002/mrd.22357.
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Transport in technicolor: mapping ATP-binding cassette transporters in sea urchin embryos.
Gökirmak T
,
Shipp LE
,
Campanale JP
,
Nicklisch SC
,
Hamdoun A
.
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One quarter of eukaryotic genes encode membrane proteins. These include nearly 1,000 transporters that translocate nutrients, signaling molecules, and xenobiotics across membranes. While it is well appreciated that membrane transport is critical for development, the specific roles of many transporters have remained cryptic, in part because of their abundance and the diversity of their substrates. Multidrug resistance ATP-binding cassette (ABC) efflux transporters are one example of cryptic membrane proteins. Although most organisms utilize these ABC transporters during embryonic development, many of these transporters have broad substrate specificity, and their developmental functions remain incompletely understood. Here, we review advances in our understanding of ABC transporters in sea urchin embryos, and methods developed to spatially and temporally map these proteins. These studies reveal that multifunctional transporters are required for signaling, homeostasis, and protection of the embryo, and shed light on how they are integrated into ancestral developmental pathways recapitulated in disease.
???displayArticle.pubmedLink??? 25156004
???displayArticle.pmcLink??? PMC4162837
???displayArticle.link??? Mol Reprod Dev
???displayArticle.grants??? [+]
K99 HD058070 NICHD NIH HHS , ES021985 NIEHS NIH HHS , R01 ES021985 NIEHS NIH HHS , HD058070 NICHD NIH HHS , R00 HD058070 NICHD NIH HHS
Genes referenced: abcb6 LOC100887844 LOC582915 LOC582918
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