Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Elife 2015 Sep 24;4. doi: 10.7554/eLife.08827.
Show Gene links Show Anatomy links

Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo.

Martik ML , McClay DR .

Gene regulatory networks (GRNs) provide a systems-level orchestration of an organism''s genome encoded anatomy. As biological networks are revealed, they continue to answer many questions including knowledge of how GRNs control morphogenetic movements and how GRNs evolve. The migration of the small micromeres to the coelomic pouches in the sea urchin embryo provides an exceptional model for understanding the genomic regulatory control of morphogenesis. An assay using the robust homing potential of these cells reveals a ''coherent feed-forward'' transcriptional subcircuit composed of Pax6, Six3, Six1/2, Eya, and Dach1 that is responsible for the directed homing mechanism of these multipotent progenitors. The linkages of that circuit are strikingly similar to a circuit involved in retinal specification in Drosophila suggesting that systems-level tasks can be highly conserved even though the tasks drive unrelated processes in different animals.

PubMed ID: 26402456
PMC ID: PMC4621380
Article link: Elife
Grant support: [+]

Species referenced: Echinodermata
Genes referenced: dach1 ddx4 eya1 foxc1 foxf1 LOC100887844 LOC100893907 LOC115919910 LOC115921237 LOC575170 pax6 pitx2 pole six1 six6 slc22a13 sox9
Morpholinos: dach1l MO1 dll1 MO3 dll1 MO4 eya1 MO1 eya1 MO2 six1 MO1 sox9 MO1

Article Images: [+] show captions
References [+] :
Andrikou, Logics and properties of a genetic regulatory program that drives embryonic muscle development in an echinoderm. 2015, Pubmed, Echinobase