ECB-ART-47762
EMBO J
2002 Aug 01;2115:4026-36. doi: 10.1093/emboj/cdf400.
Show Gene links
Show Anatomy links
Mos is not required for the initiation of meiotic maturation in Xenopus oocytes.
Dupré A
,
Jessus C
,
Ozon R
,
Haccard O
.
Abstract
In Xenopus oocytes, the c-mos proto-oncogene product has been proposed to act downstream of progesterone to control the entry into meiosis I, the transition from meiosis I to meiosis II, which is characterized by the absence of S phase, and the metaphase II arrest seen prior to fertilization. Here, we report that inhibition of Mos synthesis by morpholino antisense oligonucleotides does not prevent the progesterone-induced initiation of Xenopus oocyte meiotic maturation, as previously thought. Mos-depleted oocytes complete meiosis I but fail to arrest at metaphase II, entering a series of embryonic-like cell cycles accompanied by oscillations of Cdc2 activity and DNA replication. We propose that the unique and conserved role of Mos is to prevent mitotic cell cycles of the female gamete until the fertilization in Xenopus, starfish and mouse oocytes.
PubMed ID: 12145203
PMC ID: PMC126146
Article link: EMBO J
Genes referenced: LOC100889124 LOC115919910 LOC115928674 LOC590297 mos
References [+] :
Ballantyne,
A dependent pathway of cytoplasmic polyadenylation reactions linked to cell cycle control by c-mos and CDK1 activation.
1997, Pubmed
Ballantyne, A dependent pathway of cytoplasmic polyadenylation reactions linked to cell cycle control by c-mos and CDK1 activation. 1997, Pubmed
Bhatt, The protein kinase p90 rsk as an essential mediator of cytostatic factor activity. 1999, Pubmed
Choi, Mos/mitogen-activated protein kinase can induce early meiotic phenotypes in the absence of maturation-promoting factor: a novel system for analyzing spindle formation during meiosis I. 1996, Pubmed
Colledge, Disruption of c-mos causes parthenogenetic development of unfertilized mouse eggs. 1994, Pubmed
Daar, A characterization of cytostatic factor activity from Xenopus eggs and c-mos-transformed cells. 1991, Pubmed
Dalby, Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK. 1998, Pubmed
Davies, Specificity and mechanism of action of some commonly used protein kinase inhibitors. 2000, Pubmed
Detwiler, Two zinc finger proteins, OMA-1 and OMA-2, are redundantly required for oocyte maturation in C. elegans. 2001, Pubmed
Durocher, Detection of phosphotyrosine in glutaraldehyde-crosslinked and alkali-treated phosphoproteins following their partial acid hydrolysis in gels. 1994, Pubmed
Ferby, A novel p34(cdc2)-binding and activating protein that is necessary and sufficient to trigger G(2)/M progression in Xenopus oocytes. 1999, Pubmed
Fisher, Evidence for two catalytically active kinase domains in pp90rsk. 1996, Pubmed
Fisher, Dissociation of MAP kinase activation and MPF activation in hormone-stimulated maturation of Xenopus oocytes. 1999, Pubmed
Frank-Vaillant, Two distinct mechanisms control the accumulation of cyclin B1 and Mos in Xenopus oocytes in response to progesterone. 1999, Pubmed
Furuno, Suppression of DNA replication via Mos function during meiotic divisions in Xenopus oocytes. 1994, Pubmed
Gerhart, Cell cycle dynamics of an M-phase-specific cytoplasmic factor in Xenopus laevis oocytes and eggs. 1984, Pubmed
Gross, A constitutively active form of the protein kinase p90Rsk1 is sufficient to trigger the G2/M transition in Xenopus oocytes. 2001, Pubmed
Gross, The critical role of the MAP kinase pathway in meiosis II in Xenopus oocytes is mediated by p90(Rsk). 2000, Pubmed
Gross, Induction of metaphase arrest in cleaving Xenopus embryos by the protein kinase p90Rsk. 1999, Pubmed
Haccard, Induction of metaphase arrest in cleaving Xenopus embryos by MAP kinase. 1993, Pubmed
Haccard, Induction of Xenopus oocyte meiotic maturation by MAP kinase. 1995, Pubmed
Hara, A cytoplasmic clock with the same period as the division cycle in Xenopus eggs. 1980, Pubmed
Hashimoto, Parthenogenetic activation of oocytes in c-mos-deficient mice. 1994, Pubmed
Heasman, Beta-catenin signaling activity dissected in the early Xenopus embryo: a novel antisense approach. 2000, Pubmed
Huang, Biochemical and biological analysis of Mek1 phosphorylation site mutants. 1995, Pubmed
Huchon, Control of metaphase I formation in Xenopus oocyte: effects of an indestructible cyclin B and of protein synthesis. 1993, Pubmed
Jensen, 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1. 1999, Pubmed
Jessus, Tyrosine phosphorylation of p34cdc2 and p42 during meiotic maturation of Xenopus oocyte. Antagonistic action of okadaic acid and 6-DMAP. 1991, Pubmed
Jessus, Levels of microtubules during the meiotic maturation of the Xenopus oocyte. 1987, Pubmed
Kajiura-Kobayashi, The Mos/MAPK pathway is involved in metaphase II arrest as a cytostatic factor but is neither necessary nor sufficient for initiating oocyte maturation in goldfish. 2000, Pubmed
Kalab, Activation of p90rsk during meiotic maturation and first mitosis in mouse oocytes and eggs: MAP kinase-independent and -dependent activation. 1996, Pubmed
Karaiskou, Differential regulation of Cdc2 and Cdk2 by RINGO and cyclins. 2001, Pubmed
Kubiak, The metaphase II arrest in mouse oocytes is controlled through microtubule-dependent destruction of cyclin B in the presence of CSF. 1993, Pubmed
Lenormand, Speedy: a novel cell cycle regulator of the G2/M transition. 1999, Pubmed
Masui, Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes. 1971, Pubmed
Nebreda, Newly synthesized protein(s) must associate with p34cdc2 to activate MAP kinase and MPF during progesterone-induced maturation of Xenopus oocytes. 1995, Pubmed
Nebreda, Regulation of the meiotic cell cycle in oocytes. 2000, Pubmed
Nebreda, The protein kinase mos activates MAP kinase kinase in vitro and stimulates the MAP kinase pathway in mammalian somatic cells in vivo. 1993, Pubmed
O'Keefe, Microinjection of antisense c-mos oligonucleotides prevents meiosis II in the maturing mouse egg. 1989, Pubmed
O'Keefe, The c-mos gene product is required for cyclin B accumulation during meiosis of mouse eggs. 1991, Pubmed
Okumura, Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition. 2002, Pubmed , Echinobase
Oskarsson, Properties of a normal mouse cell DNA sequence (sarc) homologous to the src sequence of Moloney sarcoma virus. 1980, Pubmed
Palmer, A link between MAP kinase and p34(cdc2)/cyclin B during oocyte maturation: p90(rsk) phosphorylates and inactivates the p34(cdc2) inhibitory kinase Myt1. 1998, Pubmed
Paules, Mouse Mos protooncogene product is present and functions during oogenesis. 1989, Pubmed
Peter, A new role for Mos in Xenopus oocyte maturation: targeting Myt1 independently of MAPK. 2002, Pubmed
Posada, Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro. 1993, Pubmed
Reimann, Emi1 is required for cytostatic factor arrest in vertebrate eggs. 2002, Pubmed
Reimann, Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. 2001, Pubmed
Richards, Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK. 1999, Pubmed
Roy, Mos proto-oncogene function during oocyte maturation in Xenopus. 1996, Pubmed
Sadler, Components of the signaling pathway linking the 1-methyladenine receptor to MPF activation and maturation in starfish oocytes. 1998, Pubmed , Echinobase
Sagata, The product of the mos proto-oncogene as a candidate "initiator" for oocyte maturation. 1989, Pubmed
Sagata, The c-mos proto-oncogene product is a cytostatic factor responsible for meiotic arrest in vertebrate eggs. 1989, Pubmed
Sagata, Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes. 1988, Pubmed
Shibuya, Mos induces the in vitro activation of mitogen-activated protein kinases in lysates of frog oocytes and mammalian somatic cells. 1993, Pubmed
Summerton, Morpholino antisense oligomers: design, preparation, and properties. 1997, Pubmed
Tachibana, c-Mos forces the mitotic cell cycle to undergo meiosis II to produce haploid gametes. 2000, Pubmed , Echinobase
Tachibana, MAP kinase links the fertilization signal transduction pathway to the G1/S-phase transition in starfish eggs. 1997, Pubmed , Echinobase
Thoma, Generation of stable mRNA fragments and translation of N-truncated proteins induced by antisense oligodeoxynucleotides. 2001, Pubmed
Vée, Evidence for a role of the (alpha)-tubulin C terminus in the regulation of cyclin B synthesis in developing oocytes. 2001, Pubmed , Echinobase
Verlhac, Microtubule and chromatin behavior follow MAP kinase activity but not MPF activity during meiosis in mouse oocytes. 1994, Pubmed
Verlhac, Mos is required for MAP kinase activation and is involved in microtubule organization during meiotic maturation in the mouse. 1996, Pubmed
Winston, The exit of mouse oocytes from meiotic M-phase requires an intact spindle during intracellular calcium release. 1995, Pubmed
Yew, Meiotic initiation by the mos protein in Xenopus. 1992, Pubmed
Yew, Mos and the cell cycle: the molecular basis of the transformed phenotype. 1993, Pubmed
Zhou, Ability of the c-mos product to associate with and phosphorylate tubulin. 1991, Pubmed