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XB-PHENO-27308

Xtr Wt + rab5a CRISPR, Edwards NA et al. (2025)

Experiment + Assay: Xtr Wt + rab5a CRISPR + NF44 (immunohistochemistry)
Background: Xtr.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
CRISPR rab5a gRNA2 rab5a
 NF stage 1 whole organism
Conditions:
Assay Type Assay Stages Antibody
immunohistochemistry NF stage 44  
Anatomical Phenotypes: abnormally localised mitotic spindle, abnormal tracheoesophageal septum
Expression Phenotypes (1):
mislocalised lama1 expression in tracheoesophageal septum
Human Disease Associations: esophageal atresia/tracheoesophageal fistula
Source: Fig. 5CF
Article: XB-ART-61390, PubMed