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XB-PHENO-27304

Xtr Wt + itsn1 CRISPR, Edwards NA et al. (2025)

Experiment + Assay: Xtr Wt + itsn1 CRISPR + NF41 (immunohistochemistry)
Background: Xtr.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
CRISPR itsn1 gRNA3 itsn1
 NF stage 1 whole organism
Conditions:
Assay Type Assay Stages Antibody
immunohistochemistry NF stage 41  
Expression Phenotypes (1):
mislocalised vangl2 expression in tracheoesophageal septum
Human Disease Associations: esophageal atresia/tracheoesophageal fistula
Source: Fig. 6P
Article: XB-ART-61390, PubMed