XB-ART-45514
EMBO J
2012 Jun 13;3112:2737-46. doi: 10.1038/emboj.2012.126.
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Drugging Wnt signalling in cancer.
Polakis P
.
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Aberrant regulation of the Wnt signalling pathway has emerged as a prevalent theme in cancer biology. This chapter summarizes the research that provides a proof of concept for inhibiting Wnt signalling in cancer, the potential means by which this could be achieved, and some recent advances towards this goal. A brief discussion of molecular diagnostics and possible safety concerns is also provided.
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