XB-ART-18180
J Biol Chem
1996 May 17;27120:12036-41.
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Interaction of mtTFB and mtRNA polymerase at core promoters for transcription of Xenopus laevis mtDNA.
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Transcription of Xenopus laevis mitochondrial DNA requires mtRNA polymerase and a dissociable factor, xl-mtTFB, that is distinct from the HMG-box factor known as mtTFA. This paper presents the purification of mtTFB and characterizes its DNA binding properties. xl-mtTFB activity copurifies with a 40-kDa polypeptide on silver-stained protein gels. Activity can be recovered following elution of this 40-kDa polypeptide from an SDS-polyacrylamide gel. xl-mtTFB is capable of binding to DNA, but this binding is relatively nonspecific and is easily competed by heterologous DNA.
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Species referenced: Xenopus laevis
Genes referenced: tfam