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XB-PERS-1355
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Name: Dr. Bradley J Stith
Position: Professor
Research Description:
Dr. Stith's lab emphases studies involving tyrosine kinases (e.g., Src tyrosine kinase, which plays a role in cancer and in fertilization in the animal model system Xenopus laevis), tyrosine phosphatases, insulin action, antidiabetic glucophage (metformin), and calcium release during Xenopus fertilization. More specifically, he looks at how a lipid is produced during fertilization (the lipid is phosphatidic acid or PA), and how this lipid PA binds to and activates Src tyrosine kinase. Src then phosphorylates and activates Phospholipase C-gamma (PLCg). PLCg then breaks down the lipid called PIP2, producing IP3 which releases intracellular calcium...calcium then induces fertilization events.
Lab Memberships
Stith Lab (Principal Investigator/Director)Contact Information
Address:
University of Colorado Denver
Denver, CO
USA
Web Page: http://clas.ucdenver.edu/brad-stith-research/home