Luparello C et al. (2020), Histone Deacetylase Inhibitors from Marine Inve...

ECB-ART-49458

Biology (Basel) 2020 Nov 28;912:. doi: 10.3390/biology9120429.

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Histone Deacetylase Inhibitors from Marine Invertebrates.

Luparello C , Mauro M , Arizza V , Vazzana M .

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Histone deacetylases (HDACs) are key components of the epigenetic machinery controlling gene expression. They are involved in chromatin remodeling events via post-translational histone modifications but may also act on nonhistone proteins, influencing many fundamental cellular processes. Due to the key involvement of HDACs in serious human pathologies, including cancer, HDAC inhibitors (HDACis) have received increased attention in recent years. It is known that marine invertebrates produce significant amounts of secondary metabolites showing active pharmacological properties and an extensive spectrum of biomedical applications. The aim of this review is to gather selected studies that report the extraction and identification of marine invertebrate-derived compounds that possess HDACi properties, grouping the producing species according to their taxonomic hierarchy. The molecular, biochemical, and/or physiological aspects, where available, and modes of action of these naturally occurring HDACis will be recapitulated, taking into consideration their possible utilization for the future design of analogs with increased bioavailability and efficacy, less toxicity, and, also, higher isoform selectivity.

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	Figure 1. Specimens of Aplysinella rhax demosponge (CC BY 3.0 AU). https://bie.ala.org.au/species/urn:lsid:biodiversity.org.au:afd.taxon:e5607759-f60b-453a-b37a-30f3726d03c2#gallery.
	Figure 2. Specimen of Pseudoceratina purpurea demosponge [37].
	Figure 3. Specimens of Dendrilla lacunosa demosponge [38].
	Figure 4. Two examples of species of the genus Jaspis. (A) Jaspis coriacea (Carter, 1886) and (B) Jaspis splendens (de Laubenfels, 1954) [41].
	Figure 5. (A) Structures of psammaplin A (A) and bisaprasin (B).
	Figure 6. Structure of psammaplin C.
	Figure 7. Structure of psammaplin A-3091 [56].
	Figure 8. Image of a colony of Theonella swinhoei demosponges; http://www.marinespecies.org/aphia.php?p=image&tid=171264πc=133237. Licensed under a Creative Commons Attribution- Share Alike 3.0 License.
	Figure 9. Structures of yakushinamide (A) and (B).
	Figure 10. Two examples of species of the genus Halichondria. (A) Halichondria panicea (Pallas, 1766), taken from [60]. (B) Halichondria bowerbanki (Burton, 1930), taken from [61].
	Figure 11. Structure of halistanol sulphate.
	Figure 12. Two examples of species of the genus Mycale. (A) Mycale laevis, (Carter, 1882); CC0 1.0 (Public domain) https://serv.biokic.asu.edu/imglib/stri/misc/201605/13568_1464650224_web.jpg. (B) Mycale laxissima (Duchassaing and Michelotti, 1864); https://spongeguide.uncw.edu/imageinfo.php?img=319.
	Figure 13. Structures of azumamides A-E. (a) Yield of azumamide isolated by extraction from a marine sponge. (b) Against the crude enzymes extracted from K562 cells. (c) Yield based on wet weight [65].
	Figure 14. Two examples of species of the genus Haliclona. (A) Haliclona implexiformis (Hechtel, 1965); taken from [75]. (B) Haliclona fascigera (Hentschel, 1912); (CC BY-SA 3.0) http://www.marinespecies.org/photogallery.php?album=714πc=132819.
	Figure 15. Two examples of species of the genus Xestospongia. (A) Xestospongia testudinaria (Lamark, 1815) taken from [76]. (B) Xestospongia muta (Schmidt, 1870) taken from https://commons.wikimedia.org/wiki/File:Reef3860_-_Flickr_-_NOAA_Photo_Library.jpg (CC BY 2.0).
	Figure 16. Specimen of Petrosia alfiani demosponge [75].
	Figure 17. Structures of cyclostellettamine G (1), dehydrocyclostellettamine D (2), dehydrocyclostellettamine E, (3) and cyclostellettamine A (4) [78].
	Figure 18. Structures of cyclostellettamine N (1), cyclostellettamine Q (2), and the other eight bis-1,3-dialkylpyridinium compounds extracted from species of the genus Haliclona (3–10).
	Figure 19. Structure of halenaquinone.
	Figure 20. Specimen of Xenia elongata soft coral. (A) Photo of holotype in dry conditions. (B) Colony drawing from Dana (1846) [84].
	Figure 21. Structure of the diterpene extracted from X. elongata [85].
	Figure 22. Specimen of Holopus rangii crinoid. Muséum national d’Histoire naturelle, Paris (France), Collection: Echinoderms (IE), Specimen MNHN-IE-2013-10116; http://coldb.mnhn.fr/catalognumber/mnhn/ie/2013-10116.
	Figure 23. Structure of gymnochrome E.