Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Molecules
2020 Dec 11;2524:. doi: 10.3390/molecules25245856.
Show Gene links
Show Anatomy links
Marine-Derived Compounds and Prospects for Their Antifungal Application.
Cardoso J
,
Nakayama DG
,
Sousa E
,
Pinto E
.
???displayArticle.abstract???
The introduction of antifungals in clinical practice has an enormous impact on the provision of medical care, increasing the expectancy and quality of life mainly of immunocompromised patients. However, the emergence of pathogenic fungi that are resistant and multi-resistant to the existing antifungal therapy has culminated in fungal infections that are almost impossible to treat. Therefore, there is an urgent need to discover new strategies. The marine environment has proven to be a promising rich resource for the discovery and development of new antifungal compounds. Thus, this review summarizes more than one hundred marine natural products, or their derivatives, which are categorized according to their sources-sponges, bacteria, fungi, and sea cucumbers-as potential candidates as antifungal agents. In addition, this review focus on recent developments using marine antifungal compounds as new and effective approaches for the treatment of infections caused by resistant and multi-resistant pathogenic fungi and/or biofilm formation; other perspectives on antifungal marine products highlight new mechanisms of action, the combination of antifungal and non-antifungal agents, and the use of nanoparticles and anti-virulence therapy.
Alves,
Marine-Derived Compounds with Potential Use as Cosmeceuticals and Nutricosmetics.
2020, Pubmed
Alves,
Marine-Derived Compounds with Potential Use as Cosmeceuticals and Nutricosmetics.
2020,
Pubmed
Angawi,
Aurantoside J: a new tetramic acid glycoside from Theonella swinhoei. Insights into the antifungal potential of aurantosides.
2011,
Pubmed
Arendrup,
Multidrug-Resistant Candida: Epidemiology, Molecular Mechanisms, and Treatment.
2017,
Pubmed
Bahrami,
Distribution of Saponins in the Sea Cucumber Holothuria lessoni; the Body Wall Versus the Viscera, and Their Biological Activities.
2018,
Pubmed
,
Echinobase
Barbosa,
Targeting antimicrobial drug resistance with marine natural products.
2020,
Pubmed
Bennett,
Mycotechnology: the role of fungi in biotechnology.
1998,
Pubmed
Berbee,
Early Diverging Fungi: Diversity and Impact at the Dawn of Terrestrial Life.
2017,
Pubmed
Bhatnagar,
Immense essence of excellence: marine microbial bioactive compounds.
2010,
Pubmed
Bink,
Superoxide dismutases are involved in Candida albicans biofilm persistence against miconazole.
2011,
Pubmed
Calabro,
Poecillastrosides, Steroidal Saponins from the Mediterranean Deep-Sea Sponge Poecillastra compressa (Bowerbank, 1866).
2017,
Pubmed
Campoy,
Antifungals.
2017,
Pubmed
Choudhary,
Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials.
2017,
Pubmed
Corinaldesi,
Marine Microbial-Derived Molecules and Their Potential Use in Cosmeceutical and Cosmetic Products.
2017,
Pubmed
Costa,
Antimicrobial and Antibiofilm Activity of Chitosan on the Oral Pathogen Candida albicans.
2014,
Pubmed
De Cremer,
Stimulation of superoxide production increases fungicidal action of miconazole against Candida albicans biofilms.
2016,
Pubmed
Delattin,
Reactive oxygen species-inducing antifungal agents and their activity against fungal biofilms.
2014,
Pubmed
Denning,
Infectious Disease. How to bolster the antifungal pipeline.
2015,
Pubmed
El Amraoui,
In vitro screening of antifungal activity of marine sponge extracts against five phytopathogenic fungi.
2014,
Pubmed
El-Amraoui,
Haliscosamine: a new antifungal sphingosine derivative from the Moroccan marine sponge Haliclona viscosa.
2013,
Pubmed
El-Hossary,
Antifungal potential of marine natural products.
2017,
Pubmed
Fisher,
Worldwide emergence of resistance to antifungal drugs challenges human health and food security.
2018,
Pubmed
Fuentefria,
Antifungals discovery: an insight into new strategies to combat antifungal resistance.
2018,
Pubmed
Grossart,
Fungi in aquatic ecosystems.
2019,
Pubmed
Hadrich,
Epidemiology of antifungal susceptibility: Review of literature.
2018,
Pubmed
Haga,
Pyridone alkaloids from a marine-derived fungus, Stagonosporopsis cucurbitacearum, and their activities against azole-resistant Candida albicans.
2013,
Pubmed
Hao,
Caspofungin kills Candida albicans by causing both cellular apoptosis and necrosis.
2013,
Pubmed
Hassett,
Arctic marine fungi: biomass, functional genes, and putative ecological roles.
2019,
Pubmed
Karpiński,
Marine Macrolides with Antibacterial and/or Antifungal Activity.
2019,
Pubmed
Khattab,
Extraction, Identification and Biological Activities of Saponins in Sea Cucumber Pearsonothuria graeffei.
2018,
Pubmed
,
Echinobase
Krauss,
Fungi in freshwaters: ecology, physiology and biochemical potential.
2011,
Pubmed
Kuhn,
Antifungal susceptibility of Candida biofilms: unique efficacy of amphotericin B lipid formulations and echinocandins.
2002,
Pubmed
Kumar,
Aurantoside K, a new antifungal tetramic acid glycoside from a Fijian marine sponge of the genus Melophlus.
2012,
Pubmed
Kumar,
Three bioactive sesquiterpene quinones from the Fijian marine sponge of the genus Hippospongia.
2013,
Pubmed
Kurniasih,
Carboxymethyl chitosan as an antifungal agent on gauze.
2018,
Pubmed
LaFleur,
Candida albicans biofilms produce antifungal-tolerant persister cells.
2006,
Pubmed
Lacret,
New ikarugamycin derivatives with antifungal and antibacterial properties from Streptomyces zhaozhouensis.
2014,
Pubmed
Lee,
Novel Approaches for Efficient Antifungal Drug Action.
2018,
Pubmed
Lei,
New Metabolites and Bioactive Chlorinated Benzophenone Derivatives Produced by a Marine-Derived Fungus Pestalotiopsis heterocornis.
2017,
Pubmed
Liu,
The bioactive metabolites of the mangrove endophytic fungus Talaromyces sp. ZH-154 isolated from Kandelia candel (L.) Druce.
2010,
Pubmed
Liu,
Peniciadametizine A, a Dithiodiketopiperazine with a Unique Spiro[furan-2,7'-pyrazino[1,2-b][1,2]oxazine] Skeleton, and a Related Analogue, Peniciadametizine B, from the Marine Sponge-Derived Fungus Penicillium adametzioides.
2015,
Pubmed
Liu,
Combination of fluconazole with non-antifungal agents: a promising approach to cope with resistant Candida albicans infections and insight into new antifungal agent discovery.
2014,
Pubmed
MacMillan,
Lobocyclamides A-C, lipopeptides from a cryptic cyanobacterial mat containing Lyngbya confervoides.
2002,
Pubmed
Mehbub,
Marine sponge derived natural products between 2001 and 2010: trends and opportunities for discovery of bioactives.
2014,
Pubmed
Meng,
Efficacy of Compounds Isolated from Streptomyces olivaceus against the Morphogenesis and Virulence of Candida albicans.
2019,
Pubmed
Mi,
New Peptides Isolated from Marine Cyanobacteria, an Overview over the Past Decade.
2017,
Pubmed
Ngo,
A complex game of hide and seek: the search for new antifungals.
2016,
Pubmed
Okabe,
Macrolides from a Marine-Derived Fungus, Penicillium meleagrinum var. viridiflavum, Showing Synergistic Effects with Fluconazole against Azole-Resistant Candida albicans.
2016,
Pubmed
Ostrosky-Zeichner,
An insight into the antifungal pipeline: selected new molecules and beyond.
2010,
Pubmed
Pettit,
Specific activities of dolastatin 10 and peptide derivatives against Cryptococcus neoformans.
1998,
Pubmed
Pierce,
From Biology to Drug Development: New Approaches to Combat the Threat of Fungal Biofilms.
2015,
Pubmed
Pinto,
Aspergillus Species and Antifungals Susceptibility in Clinical Setting in the North of Portugal: Cryptic Species and Emerging Azoles Resistance in A. fumigatus.
2018,
Pubmed
Pu,
In vitro damage of Candida albicans biofilms by chitosan.
2014,
Pubmed
Pugazhendhi,
Anticancer, antimicrobial and photocatalytic activities of green synthesized magnesium oxide nanoparticles (MgONPs) using aqueous extract of Sargassum wightii.
2019,
Pubmed
Sanguinetti,
Antifungal drug resistance among Candida species: mechanisms and clinical impact.
2015,
Pubmed
Sardi,
Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options.
2013,
Pubmed
Scorzoni,
Antifungal Therapy: New Advances in the Understanding and Treatment of Mycosis.
2017,
Pubmed
Shaala,
Identification and bioactivity of compounds from the fungus Penicillium sp. CYE-87 isolated from a marine tunicate.
2015,
Pubmed
Shariatinia,
Carboxymethyl chitosan: Properties and biomedical applications.
2018,
Pubmed
Singh,
Metallic silver nanoparticle: a therapeutic agent in combination with antifungal drug against human fungal pathogen.
2013,
Pubmed
Soares-Costa,
Industrial PE-2 strain of Saccharomyces cerevisiae: from alcoholic fermentation to the production of recombinant proteins.
2014,
Pubmed
Soliman,
Nanoparticles as safe and effective delivery systems of antifungal agents: Achievements and challenges.
2017,
Pubmed
Tanabe,
Inhibition of fungal ABC transporters by unnarmicin A and unnarmicin C, novel cyclic peptides from marine bacterium.
2007,
Pubmed
Thibane,
Effect of marine polyunsaturated fatty acids on biofilm formation of Candida albicans and Candida dubliniensis.
2010,
Pubmed
Thompson,
Overview of antifungal agents.
2009,
Pubmed
Van Daele,
Antifungal drugs: What brings the future?
2019,
Pubmed
Vila,
Targeting Candida albicans filamentation for antifungal drug development.
2017,
Pubmed
Wang,
Variegatusides: new non-sulphated triterpene glycosides from the sea cucumber Stichopus variegates semper.
2014,
Pubmed
,
Echinobase
Wyche,
Forazoline A: marine-derived polyketide with antifungal in vivo efficacy.
2014,
Pubmed
Xu,
Antibacterial and antifungal compounds from marine fungi.
2015,
Pubmed
Xu,
Formamido-diterpenes from the South China Sea sponge Acanthella cavernosa.
2012,
Pubmed
Younes,
Chitin and chitosan preparation from marine sources. Structure, properties and applications.
2015,
Pubmed
Youssef,
Theonellamide G, a potent antifungal and cytotoxic bicyclic glycopeptide from the Red Sea marine sponge Theonella swinhoei.
2014,
Pubmed
Yu,
Woodylides A-C, new cytotoxic linear polyketides from the South China Sea sponge Plakortis simplex.
2012,
Pubmed
Yu,
Aaptamine derivatives with antifungal and anti-HIV-1 activities from the South China Sea sponge Aaptos aaptos.
2014,
Pubmed
Yu,
Eutypellenoids A⁻C, New Pimarane Diterpenes from the Arctic Fungus Eutypella sp. D-1.
2018,
Pubmed
Zhao,
Anti-Phytopathogenic and Cytotoxic Activities of Crude Extracts and Secondary Metabolites of Marine-Derived Fungi.
2018,
Pubmed
Zheng,
An insight into new strategies to combat antifungal drug resistance.
2018,
Pubmed
