Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
???displayArticle.abstract???
The development of novel anticancer agents is essential to finding new ways to treat this disease, one of the deadliest diseases. Some marine organisms have proved to be important producers of chemically active compounds with valuable bioactive properties, including anticancer. Thus, the ocean has proved to be a huge source of bioactive compounds, making the discovery and study of these compounds a growing area. In the last few years, several compounds of marine origin, which include algae, corals, and sea urchins, have been isolated, studied, and demonstrated to possess anticancer properties. These compounds, mainly from securamines and sterols families, have been tested for cytotoxic/antiproliferative activity in different cell lines. Bioactive compounds isolated from marine organisms in the past 5 years that have shown anticancer activity, emphasizing the ones that showed the highest cytotoxic activity, such as securamines H and I, cholest-3β,5α,6β-triol, (E)-24-methylcholest-22-ene-3β,5α,6β-triol, 24-methylenecholesta-3β,5α,6β-triol, and 24-methylcholesta-3β,5α,6β-triol, will be discussed in this review. These studies reveal the possibility of new compounds of marine origin being used as new therapeutic agents or as a source of inspiration to develop new therapeutic agents.
Abdelkarem,
Two new polyhydroxylated steroids from Egyptian soft coral Heteroxenia fuscescens (Fam.; Xeniidae).
2021, Pubmed
Abdelkarem,
Two new polyhydroxylated steroids from Egyptian soft coral Heteroxenia fuscescens (Fam.; Xeniidae).
2021,
Pubmed
Abdelkarem,
Diadema setosum: isolation of bioactive secondary metabolites with cytotoxic activity toward human cervical cancer.
2022,
Pubmed
,
Echinobase
Abu-Khudir,
Antimicrobial, Antioxidant, and Anti-Tumor Activities of Sargassum linearifolium and Cystoseira crinita from Egyptian Mediterranean Coast.
2021,
Pubmed
Boeuf,
Marine biodiversity characteristics.
2011,
Pubmed
Cheng,
Bioactive polyhydroxylated sterols from the marine sponge Haliclona crassiloba.
2013,
Pubmed
Ciftci,
Anticancer activity of Turkish marine extracts: a purple sponge extract induces apoptosis with multitarget kinase inhibition activity.
2020,
Pubmed
,
Echinobase
De La Fuente,
The Remarkable Antioxidant and Anti-Inflammatory Potential of the Extracts of the Brown Alga Cystoseira amentacea var. stricta.
2020,
Pubmed
Dyshlovoy,
Marine Compounds and Cancer: 2017 Updates.
2018,
Pubmed
Elshamy,
A new gorgostane derivative from the Egyptian Red Sea soft coral Heteroxenia ghardaqensis.
2013,
Pubmed
Ercolano,
New Drugs from the Sea: Pro-Apoptotic Activity of Sponges and Algae Derived Compounds.
2019,
Pubmed
Faulkner,
Highlights of marine natural products chemistry (1972-1999).
2000,
Pubmed
Feinberg,
The epigenetic progenitor origin of human cancer.
2006,
Pubmed
Ferlay,
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.
2015,
Pubmed
Gurib-Fakim,
Medicinal plants: traditions of yesterday and drugs of tomorrow.
2006,
Pubmed
Hansen,
Securamine Derivatives from the Arctic Bryozoan Securiflustra securifrons.
2017,
Pubmed
Hegazy,
A new steroid from the Red Sea soft coral Lobophytum lobophytum.
2016,
Pubmed
Indrayanto,
Validation of in-vitro bioassay methods: Application in herbal drug research.
2021,
Pubmed
Kamyab,
Chemical Defense Mechanisms and Ecological Implications of Indo-Pacific Holothurians.
2020,
Pubmed
,
Echinobase
Khalifa,
Marine Natural Products: A Source of Novel Anticancer Drugs.
2019,
Pubmed
Korakas,
Efficient construction of the securine A carbon skeleton.
2004,
Pubmed
Li,
Polyoxygenated sterols from the South China Sea soft coral Sinularia sp.
2012,
Pubmed
Liby,
Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer.
2007,
Pubmed
Martins,
Macroalgae Extracts From Antarctica Have Antimicrobial and Anticancer Potential.
2018,
Pubmed
Minh,
Cytotoxic constituents of Diadema setosum.
2004,
Pubmed
,
Echinobase
Newman,
Natural Products as Sources of New Drugs from 1981 to 2014.
2016,
Pubmed
Newman,
Natural products as sources of new drugs over the 30 years from 1981 to 2010.
2012,
Pubmed
Nikolaou,
The challenge of drug resistance in cancer treatment: a current overview.
2018,
Pubmed
Pereira,
Anti-Inflammatory Effects of 5α,8α-Epidioxycholest-6-en-3β-ol, a Steroidal Endoperoxide Isolated from Aplysia depilans, Based on Bioguided Fractionation and NMR Analysis.
2019,
Pubmed
Peña-Morán,
Cytotoxicity, Post-Treatment Recovery, and Selectivity Analysis of Naturally Occurring Podophyllotoxins from Bursera fagaroides var. fagaroides on Breast Cancer Cell Lines.
2016,
Pubmed
Rabi,
Terpenoids and breast cancer chemoprevention.
2009,
Pubmed
Rahelivao,
Isolation and structure elucidation of natural products of three soft corals and a sponge from the coast of Madagascar.
2017,
Pubmed
Rocha,
Seaweed Secondary Metabolites In Vitro and In Vivo Anticancer Activity.
2018,
Pubmed
Roje-Busatto,
PSP toxins profile in ascidian Microcosmus vulgaris (Heller, 1877) after human poisoning in Croatia (Adriatic Sea).
2014,
Pubmed
Rosa,
Seaweed Secondary Metabolites with Beneficial Health Effects: An Overview of Successes in In Vivo Studies and Clinical Trials.
2019,
Pubmed
Ruiz-Torres,
An Updated Review on Marine Anticancer Compounds: The Use of Virtual Screening for the Discovery of Small-Molecule Cancer Drugs.
2017,
Pubmed
Sawadogo,
A Survey of Marine Natural Compounds and Their Derivatives with Anti-cancer Activity Reported in 2012.
2015,
Pubmed
Seca,
Plant Secondary Metabolites as Anticancer Agents: Successes in Clinical Trials and Therapeutic Application.
2018,
Pubmed
Shinde,
Marine natural products as source of new drugs: a patent review (2015-2018).
2019,
Pubmed
Sithranga Boopathy,
Anticancer drugs from marine flora: an overview.
2010,
Pubmed
Smyrniotopoulos,
Density Functional Theory (DFT)-Aided Structure Elucidation of Linear Diterpenes from the Irish Brown Seaweed Bifurcaria bifurcata.
2021,
Pubmed
Sun,
Recent advances in cancer immunotherapy.
2017,
Pubmed
Sun,
Isolation of a new cytotoxic polyhydroxysterol from the South China Sea soft coral Sinularia sp.
2016,
Pubmed
Tarhouni-Jabberi,
Mertensene, a Halogenated Monoterpene, Induces G2/M Cell Cycle Arrest and Caspase Dependent Apoptosis of Human Colon Adenocarcinoma HT29 Cell Line through the Modulation of ERK-1/-2, AKT and NF-κB Signaling.
2017,
Pubmed
Wali,
Natural products against cancer: Review on phytochemicals from marine sources in preventing cancer.
2019,
Pubmed
Walsh,
Cancer chemotherapy, biodiversity, public and private property: the case of the anti-cancer drug taxol.
1999,
Pubmed
Wang,
Bioactive polyoxygenated steroids from the South China sea soft coral, Sarcophyton sp.
2013,
Pubmed
White,
Age and cancer risk: a potentially modifiable relationship.
2014,
Pubmed
Woo,
Two new pyrrolo-2-aminoimidazoles from a Myanmarese marine sponge, Clathria prolifera.
2018,
Pubmed
van Ofwegen,
Sinularia leptoclados (Ehrenberg, 1834) (Cnidaria, Octocorallia) re-examined.
2013,
Pubmed