Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Mar Drugs
2021 Jul 26;198:. doi: 10.3390/md19080412.
Show Gene links
Show Anatomy links
Multifaceted Clinical Effects of Echinochrome.
Kim HK
,
Vasileva EA
,
Mishchenko NP
,
Fedoreyev SA
,
Han J
.
???displayArticle.abstract???
The marine drug histochrome is a special natural antioxidant. The active substance of the drug is echinochrome A (Ech A, 7-ethyl-2,3,5,6,8-pentahydroxy-1,4-naphthoquinone), the most abundant quinonoid pigment in sea urchins. The medicine is clinically used in cardiology and ophthalmology based on the unique properties of Ech A, which simultaneously block various links of free radical reactions. In the last decade, numerous studies have demonstrated the effectiveness of histochrome in various disease models without adverse effects. Here, we review the data on the various clinical effects and modes of action of Ech A in ophthalmic, cardiovascular, cerebrovascular, inflammatory, metabolic, and malignant diseases.
2018R1D1A1A09081767 National Research Foundation of Korea, 2020R1A4A1018943 National Research Foundation of Korea, 2018R1A2A3074998 National Research Foundation of Korea
Afanas'ev,
[The effect of histochrome on the lipid peroxidation indices during the surgical treatment of patients with ischemic heart disease of different functional classes].
1999, Pubmed
Afanas'ev,
[The effect of histochrome on the lipid peroxidation indices during the surgical treatment of patients with ischemic heart disease of different functional classes].
1999,
Pubmed
Afanasiev,
[ATP-preserving effect of histochrome during acute myocardial ischemia in patients with ischemic heart disease].
1997,
Pubmed
Agafonova,
Effect of histochrome on brain vessels and research and exploratory activity of senescence-accelerated OXYS rats.
2007,
Pubmed
Anderson,
Distribution of spinochrome pigments in echinoids.
1969,
Pubmed
,
Echinobase
Artyukov,
Marine Polyhydroxynaphthoquinone, Echinochrome A: Prevention of Atherosclerotic Inflammation and Probable Molecular Targets.
2020,
Pubmed
,
Echinobase
Babenkova,
[Antioxidative activity of histochrome and some other drugs used in ophthalmology].
1999,
Pubmed
Bernikova,
Effect of Water-Soluble Echinochrome Analog on Arrhythmia Severity in Experimental Model of Acute Myocardial Ischemia.
2018,
Pubmed
,
Echinobase
Buĭmov,
[Effect of the bioantioxidant histochrome on myocardial injury in reperfusion therapy on patients with myocardial infarction].
2002,
Pubmed
Chiusa,
Sodium nitroprusside induces cell death and cytoskeleton degradation in adult rat cardiomyocytes in vitro: implications for anthracycline-induced cardiotoxicity.
2012,
Pubmed
Egorov,
[Histochrome, a new antioxidant, in the treatment of ocular diseases].
1999,
Pubmed
Fahmy,
Protective effect of Echinochrome against intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats.
2020,
Pubmed
Fahmy,
Effectiveness of Echinochrome on HFD-Induced Hyperlipidemia in Rats.
2019,
Pubmed
Fields,
Protein kinase C iota: human oncogene, prognostic marker and therapeutic target.
2007,
Pubmed
Gakhramanov,
Use of natural antioxidants for the correction of changes in general and local parameters of lipid peroxidation and antioxidant defense system during experimental eye burn.
2006,
Pubmed
Grysiewicz,
Epidemiology of ischemic and hemorrhagic stroke: incidence, prevalence, mortality, and risk factors.
2008,
Pubmed
Gusev,
[An influence of histochrome on the dynamics of neurological disorders and MRT-picture in experimental hemorrhagic stroke].
2005,
Pubmed
Guseva,
[The specific features of penetration of the antioxidant histochrome across the blood-ocular barrier: an experimental study].
2007,
Pubmed
Jeong,
Echinochrome A protects mitochondrial function in cardiomyocytes against cardiotoxic drugs.
2014,
Pubmed
,
Echinobase
Jeong,
Echinochrome a increases mitochondrial mass and function by modulating mitochondrial biogenesis regulatory genes.
2014,
Pubmed
,
Echinobase
Kim,
Echinochrome A regulates phosphorylation of phospholamban Ser16 and Thr17 suppressing cardiac SERCA2A Ca²⁺ reuptake.
2015,
Pubmed
,
Echinobase
Kim,
Cardiac proteomic responses to ischemia-reperfusion injury and ischemic preconditioning.
2011,
Pubmed
Kim,
Echinochrome A Attenuates Cerebral Ischemic Injury through Regulation of Cell Survival after Middle Cerebral Artery Occlusion in Rat.
2019,
Pubmed
,
Echinobase
Kim,
A Novel Atypical PKC-Iota Inhibitor, Echinochrome A, Enhances Cardiomyocyte Differentiation from Mouse Embryonic Stem Cells.
2018,
Pubmed
,
Echinobase
Kruk,
The Role Oxidative Stress in the Pathogenesis of Eye Diseases: Current Status and a Dual Role of Physical Activity.
2015,
Pubmed
Lasukova,
[Effects of emoxipine and histochrome on lipid peroxidation and activity of serum MB-creatine phosphokinase in patients with ischemic heart disease during aortocoronary shunting].
1997,
Pubmed
Lebedev,
Iron chelators and free radical scavengers in naturally occurring polyhydroxylated 1,4-naphthoquinones.
2008,
Pubmed
Lebedev,
[Mechanisms of the inhibition of Fe2+-induced oxidation of phosphatidylcholine by polyhydroxynaphthoquinones].
1988,
Pubmed
Lebedev,
Interaction of natural polyhydroxy-1,4-naphthoquinones with superoxide anion-radical.
1999,
Pubmed
Lee,
NecroX-5 suppresses sodium nitroprusside-induced cardiac cell death through inhibition of JNK and caspase-3 activation.
2014,
Pubmed
Lennikov,
Amelioration of endotoxin-induced uveitis treated with the sea urchin pigment echinochrome in rats.
2014,
Pubmed
,
Echinobase
Michael,
Inflammation Shapes Stem Cells and Stemness during Infection and Beyond.
2016,
Pubmed
Mischenko,
Effects of histochrom and emoxypin on biophysical properties of electroexitable cells.
2009,
Pubmed
Mishchenko,
Antiviral Potential of Sea Urchin Aminated Spinochromes against Herpes Simplex Virus Type 1.
2020,
Pubmed
,
Echinobase
Mohamed,
Hepatoprotective Effect of Echinochrome Pigment in Septic Rats.
2019,
Pubmed
,
Echinobase
Mohamed,
The Possible Hypoglycemic Mechanisms of Echinochrome.
2018,
Pubmed
,
Echinobase
Mohamed,
Mechanisms of echinochrome potency in modulating diabetic complications in liver.
2016,
Pubmed
,
Echinobase
Mohamed,
Echinochrome Exhibits Antitumor Activity against Ehrlich Ascites Carcinoma in Swiss Albino Mice.
2021,
Pubmed
,
Echinobase
Murray,
Aryl hydrocarbon receptor ligands in cancer: friend and foe.
2014,
Pubmed
Nikolaeva,
[Analysis of efficacy of prevention and antioxidant therapy in premature infants].
2012,
Pubmed
Oh,
Echinochrome A Reduces Colitis in Mice and Induces In Vitro Generation of Regulatory Immune Cells.
2019,
Pubmed
,
Echinobase
Park,
Echinochrome A Treatment Alleviates Fibrosis and Inflammation in Bleomycin-Induced Scleroderma.
2021,
Pubmed
,
Echinobase
Park,
Therapeutic Cell Protective Role of Histochrome under Oxidative Stress in Human Cardiac Progenitor Cells.
2019,
Pubmed
,
Echinobase
Park,
Echinochrome A Promotes Ex Vivo Expansion of Peripheral Blood-Derived CD34+ Cells, Potentially through Downregulation of ROS Production and Activation of the Src-Lyn-p110δ Pathway.
2019,
Pubmed
Saraiva,
HLA-DR in Cytotoxic T Lymphocytes Predicts Breast Cancer Patients' Response to Neoadjuvant Chemotherapy.
2018,
Pubmed
Sayed,
Echinochrome pigment as novel therapeutic agent against experimentally - induced gastric ulcer in rats.
2018,
Pubmed
,
Echinobase
Sedova,
Effects of echinochrome on ventricular repolarization in acute ischemia.
2015,
Pubmed
Shvilkin,
[Effect of echinochrom on experimental myocardial reperfusion injury].
1991,
Pubmed
Stonik,
Development of medicines for hemorrhage stroke: the use of magnetic resonance tomography for estimating the effectiveness of histochrome.
2005,
Pubmed
Vasileva,
New Aminonaphthoquinone from the Sea Urchins Strongylocentrotus pallidus and Mesocentrotus nudus.
2016,
Pubmed
,
Echinobase
Vichier-Guerre,
Induction of carbohydrate-specific antibodies in HLA-DR transgenic mice by a synthetic glycopeptide: a potential anti cancer vaccine for human use.
2003,
Pubmed
Vinokurov,
[Effect of antioxidant histochrome preparation on the contractile function and metabolism of the isolated rat heart under conditions of "calcium paradox", ischemia, and reperfusion].
2001,
Pubmed
Yoon,
Spinochrome D Attenuates Doxorubicin-Induced Cardiomyocyte Death via Improving Glutathione Metabolism and Attenuating Oxidative Stress.
2018,
Pubmed
,
Echinobase
Zakirova,
[The antioxidant histochrome: its effect on lipid peroxidation and the blood rheological properties in patients with unstable stenocardia].
1996,
Pubmed
Zakirova,
[Pharmacokinetics and clinical efficacy of histochrome in patients with acute myocardial infarction].
1997,
Pubmed
