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ECB-ART-48953
Bull Exp Biol Med 2021 Aug 01;1714:464-467. doi: 10.1007/s10517-021-05251-y.
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Comparative In Vitro Study of Antiherpetic Activity of Echinochrome A and Product of Its Oxidation Dehydroechinochrome.

Iunikhina OV , Krylova NV , Mishchenko NP , Vasileva EA , Fedoreyev SA , Shchelkanov MY .


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The quinoid pigment echinochrome A isolated from the sea urchin Scaphechinus mirabilis, the product of its oxidation dehydroechinochrome, and structurally similar antiviral agent oxolin were tested for their ability to inhibit plaque formation induced by herpes simplex virus type 1 (HSV-1) in Vero cells. The tested compounds showed significant anti-HSV-1 activity, mainly due to their direct effect on viral particles and on virus attachment to cells. The antiviral efficacy of the test compounds increased in the following order: oxolin→echinochrome A→dehydroechinochrome.

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