Zhuravleva OI et al. (2019), Virescenosides From the Holothurian-Associated ...

ECB-ART-48844

Mar Drugs 2019 Oct 29;1711:. doi: 10.3390/md17110616.

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Virescenosides From the Holothurian-Associated Fungus Acremonium Striatisporum Kmm 4401.

Zhuravleva OI , Antonov AS , Oleinikova GK , Khudyakova YV , Popov RS , Denisenko VA , Pislyagin EA , Chingizova EA , Afiyatullov SS .

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Ten new diterpene glycosides virescenosides Z9-Z18 (1-10) together with three known analogues (11-13) and aglycon of virescenoside A (14) were isolated from the marine-derived fungus Acremonium striatisporum KMM 4401. These compounds were obtained by cultivating fungus on wort agar medium with the addition of potassium bromide. Structures of the isolated metabolites were established based on spectroscopic methods. The effects of some isolated glycosides and aglycons 15-18 on urease activity and regulation of Reactive Oxygen Species (ROS) and Nitric Oxide (NO) production in macrophages stimulated with lipopolysaccharide (LPC) were evaluated.

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Genes referenced: LOC583434 ros1

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References [+] :

Afiyatullov, New diterpene glycosides of the fungus Acremonium striatisporum isolated from a sea cucumber. 2002, Pubmed, Echinobase

	Figure 1. Chemical structures of 1–10.
	Figure 2. Key HMBC and NOESY correlations of 1.
	Figure 3. Influence of compounds upon ROS level in murine peritoneal macrophages, co-incubated with LPS from E. coli. The compounds were tested at a concentration of 10 μM. Time of cell incubation with compounds was 1 h at 37 °C. * p < 0.05.
	Figure 4. Influence of compounds upon RNS level in murine peritoneal macrophages, co-incubated with LPS from E. coli. The compounds were tested at a concentration of 1 μM. Time of cell incubation with compounds was 1 h at 37 °C. * p < 0.05.