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Res Pharm Sci
2019 Oct 01;145:432-440. doi: 10.4103/1735-5362.268204.
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Phytochemical analysis of Holothuria leucospilota, a sea cucumber from Persian Gulf.
Shushizadeh MR
,
Mohammadi Pour P
,
Mahdieh M
,
Yegdaneh A
.
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Sea cucumbers are widely consumed in traditional medicine and food. These animals have a considerable secondary metabolite and also several potential biological activities. This study investigated the phytochemical and cytotoxic evaluation of Holothuria leucospilota (H. leucospilota), a sea cucumber from Persian Gulf. The saponin composition of H. leucospilota was studied by different partitioning and chromatography methods such as thin layer chromatography (TLC), medium pressure liquid chromatography (MPLC) and high performance LC (HPLC). The marine sea cucumber Holostane-type triterpenoids (1-3) were characterized by physical and spectroscopic examination (1 and 2 dimensional neuclear magnetic resonance and mass experiments) with data analysis. The structure of compounds 1-3 identified as echinoside A, holothurine A, and 24-dehydroechinoside A, showed moderate cytotoxic activity with IC50 values of 1.9 ± 0.07, 6.8 ± 0.23, and 2.57 ± 0.18 μg/mL against HeLa and 10.4 ± 0.32, 8.9 ± 0.24, and 4.4 ± 0.13 on HUVEC cell line, respectively. In conclusion, the holostane-type triterpenoids showed moderate cytotoxic activity against HeLa cell line and have a prosperous future to be introduced as a lead structure.
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Bordbar,
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,
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Caulier,
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,
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Dong,
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Fenical,
Developing a new resource for drug discovery: marine actinomycete bacteria.
2006,
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Grauso,
Molecular Networking-Based Analysis of Cytotoxic Saponins from Sea Cucumber Holothuria atra.
2019,
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,
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Han,
A novel sulfated holostane glycoside from sea cucumber Holothuria leucospilota.
2010,
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,
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Himaya,
Sea cucumber, Stichopus japonicus ethyl acetate fraction modulates the lipopolysaccharide induced iNOS and COX-2 via MAPK signaling pathway in murine macrophages.
2010,
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,
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Kalinin,
System-theoretical (Holistic) approach to the modelling of structural-functional relationships of biomolecules and their evolution: an example of triterpene glycosides from sea cucumbers (Echinodermata, holothurioidea).
2000,
Pubmed
,
Echinobase
Li,
Basic and clinical study on the antithrombotic mechanism of glycosaminoglycan extracted from sea cucumber.
2000,
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,
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Li,
Echinoside A, a new marine-derived anticancer saponin, targets topoisomerase2alpha by unique interference with its DNA binding and catalytic cycle.
2010,
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,
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Munro,
The discovery and development of marine compounds with pharmaceutical potential.
1999,
Pubmed
Sawadogo,
A Survey of Marine Natural Compounds and Their Derivatives with Anti-cancer Activity Reported in 2012.
2015,
Pubmed
Schillaci,
Immune mediators of sea-cucumber Holothuria tubulosa (Echinodermata) as source of novel antimicrobial and anti-staphylococcal biofilm agents.
2013,
Pubmed
,
Echinobase
Tian,
PE, a new sulfated saponin from sea cucumber, exhibits anti-angiogenic and anti-tumor activities in vitro and in vivo.
2005,
Pubmed
,
Echinobase
Van Dyck,
Qualitative and quantitative saponin contents in five sea cucumbers from the Indian ocean.
2010,
Pubmed
,
Echinobase
Van Dyck,
The triterpene glycosides of Holothuria forskali: usefulness and efficiency as a chemical defense mechanism against predatory fish.
2011,
Pubmed
,
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Wang,
Effects of two sulfated triterpene saponins echinoside A and holothurin A on the inhibition of dietary fat absorption and obesity reduction.
2014,
Pubmed
,
Echinobase
Wijesinghe,
Anticancer activity and mediation of apoptosis in human HL-60 leukaemia cells by edible sea cucumber (Holothuria edulis) extract.
2013,
Pubmed
,
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Wu,
Structure and effect of sulfated fucose branches on anticoagulant activity of the fucosylated chondroitin sulfate from sea cucumber Thelenata ananas.
2012,
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,
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Ye,
Anticancer effects of echinacoside in hepatocellular carcinoma mouse model and HepG2 cells.
2019,
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Zhao,
Saponins from Sea Cucumber and Their Biological Activities.
2018,
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,
Echinobase
Zhao,
Ds-echinoside A, a new triterpene glycoside derived from sea cucumber, exhibits antimetastatic activity via the inhibition of NF-κB-dependent MMP-9 and VEGF expressions.
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,
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Zhao,
Differential effects of sulfated triterpene glycosides, holothurin A1, and 24-dehydroechinoside A, on antimetastasic activity via regulation of the MMP-9 signal pathway.
2010,
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,
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Zhao,
In vitro and in vivo anti-tumour activities of echinoside A and ds-echinoside A from Pearsonothuria graeffei.
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,
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