Lazzara V et al. (2019), Bright Spots in The Darkness of Cancer: A Revie...

ECB-ART-47525

Mar Drugs 2019 Oct 29;1711:. doi: 10.3390/md17110617.

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Bright Spots in The Darkness of Cancer: A Review of Starfishes-Derived Compounds and Their Anti-Tumor Action.

Lazzara V , Arizza V , Luparello C , Mauro M , Vazzana M .

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The fight against cancer represents a great challenge for researchers and, for this reason, the search for new promising drugs to improve cancer treatments has become inevitable. Oceans, due to their wide diversity of marine species and environmental conditions have proven to be precious sources of potential natural drugs with active properties. As an example, in this context several studies performed on sponges, tunicates, mollusks, and soft corals have brought evidence of the interesting biological activities of the molecules derived from these species. Also, echinoderms constitute an important phylum, whose members produce a huge number of compounds with diverse biological activities. In particular, this review is the first attempt to summarize the knowledge about starfishes and their secondary metabolites that exhibited a significant anticancer effect against different human tumor cell lines. For each species of starfish, the extracted molecules, their effects, and mechanisms of action are described.

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Genes referenced: LOC100893907 LOC115919910

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References [+] :

Amemiya, Echinoderms. 2005, Pubmed, Echinobase

	Figure 1. Acanthaster planci [19]. © Craig Howe (CC BY-NC-ND).
	Figure 2. Anthenea aspera [28].
	Figure 3. Archaster typicus [31]. © budak. Some rights reserved (CC-BY-NC).
	Figure 4. Asterias amurensis [34].
	Figure 5. Asterina pectinifera [40]. © Alexander Semenov.
	Figure 6. Asteropsis carinifera [49]. © P. Bourjon.
	Figure 7. Astropecten polyacanthus [52]. © Chaloklum Diving CC-BY-3.0 (https://commons.wikimedia.org).
	Figure 8. Astropecten monacanthus [55].

	Figure 10. Craspidaster Hesperus [67]. © budak, Some Right Reserved (CC BY-NC).
	Figure 11. Ctenodiscus crispatus [69]. © Rick (https://www.flickr.com).
	Figure 12. Culcita novaeguineae [71]. © Western Australian Museum Collections (CC BY 4.0).
	Figure 13. Echinaster luzonicus [79]. © Bernard Dupont (CC-BY-SA-2.0).
	Figure 14. Henricia leviuscula [81]. © Christopher Lindsey.
	Figure 15. Hippasteria phrygiana [83]. © Viktor V. Grøtan, some right reserved (CC BY-NC).
	Figure 16. Narcissia canariensis [89].