Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Int J Mol Sci
2019 Sep 24;2019:. doi: 10.3390/ijms20194738.
Show Gene links
Show Anatomy links
Holothuria Leucospilota Polysaccharides Ameliorate Hyperlipidemia in High-Fat Diet-Induced Rats via Short-Chain Fatty Acids Production and Lipid Metabolism Regulation.
Yuan Y
,
Liu Q
,
Zhao F
,
Cao J
,
Shen X
,
Li C
.
???displayArticle.abstract???
Holothuria leucospilota polysaccharides (HLP) are expected to become potential resources for the treatment of hyperlipidemia because of their various bioactivities. In the study, the treatment of HLP on improving hyperlipidemia in rats was explored. Oral administration of HLP at 100 or 200 mg/kg body weight effectively alleviated serum lipid levels and liver histological abnormalities in high-fat-diet rats. HLP regulated abnormal mRNA, lipogenesis-related hormones and inflammatory cytokines (tumor necrosis factor-α, interleukin-6 and interleukin-12) levels. HLP improved the ability of gut microbiota to produce short-chain fatty acids (SCFAs). SCFAs have been found to ameliorate liver lesions. Therefore, HLP alleviated hyperlipidemia by improving the levels of SCFAs to regulate lipid metabolism. These results indicated that HLP could be used as beneficial polysaccharides to alleviate hyperlipidemia.
HHCL201804 the Project of Haikou Ocean and Fisheries Bureau, 2017051 the Key Project of Science and Technology of Haikou, KYQD1609 the Scientific Research Foundation of Hainan University
Figure 3. Effects of HLP on the gut microbiota. Principal component analysis (PCA) score plot for the gut microbiota (A). The bacterial community at the genus level in the guts of the rats (B) (n = 6).
Figure 4. Effects of HLP on short-chain fatty acids (SCFAs). The content of SCFAs in feces (A). PCA score plot for SCFAs (B) (n = 8).
Figure 7. Summary of the mechanism of HLP to prevent hyperlipidemia.
Cao,
Recent AHA/ACC guidelines on cholesterol management expands the role of the clinical laboratory.
2019, Pubmed
Cao,
Recent AHA/ACC guidelines on cholesterol management expands the role of the clinical laboratory.
2019,
Pubmed
El-Shinnawy,
Ameliorative role of camel whey protein and rosuvastatin on induced dyslipidemia in mice.
2018,
Pubmed
Gangadaran,
A high fat diet enriched with sea cucumber gut powder provides cardio-protective and anti-obesity effects in C57BL/6 mice.
2017,
Pubmed
,
Echinobase
Guarner,
Decade in review-gut microbiota: the gut microbiota era marches on.
2014,
Pubmed
Han,
Effects of Whole-Grain Rice and Wheat on Composition of Gut Microbiota and Short-Chain Fatty Acids in Rats.
2018,
Pubmed
Harvey,
The re-emergence of natural products for drug discovery in the genomics era.
2015,
Pubmed
Hu,
Fucosylated chondroitin sulfate from sea cucumber improves insulin sensitivity via activation of PI3K/PKB pathway.
2014,
Pubmed
,
Echinobase
Jay,
The enigmatic membrane fatty acid transporter CD36: New insights into fatty acid binding and their effects on uptake of oxidized LDL.
2018,
Pubmed
Konikoff,
Oscillospira: a Central, Enigmatic Component of the Human Gut Microbiota.
2016,
Pubmed
Korolenko,
Hypolipidemic effect of mannans from C. albicans serotypes a and B in acute hyperlipidemia in mice.
2018,
Pubmed
Li,
Macromolecular properties and hypolipidemic effects of four sulfated polysaccharides from sea cucumbers.
2017,
Pubmed
,
Echinobase
Malik,
Relationship among obesity, blood lipids and insulin resistance in Bangladeshi adults.
2019,
Pubmed
Nakandakari,
Short-term high-fat diet modulates several inflammatory, ER stress, and apoptosis markers in the hippocampus of young mice.
2019,
Pubmed
Nepomuceno,
Systemic expression of genes related to inflammation and lipid metabolism in patients with dyslipidemia, type 2 diabetes mellitus and chronic periodontitis.
2019,
Pubmed
Shang,
Gut microbiota fermentation of marine polysaccharides and its effects on intestinal ecology: An overview.
2018,
Pubmed
Shirpoor,
Increased hepatic FAT/CD36, PTP1B and decreased HNF4A expression contributes to dyslipidemia associated with ethanol-induced liver dysfunction: Rescue effect of ginger extract.
2018,
Pubmed
Song,
IL-6 and the acute phase response in murine atherosclerosis.
2004,
Pubmed
Stanley,
Effects of growth hormone-releasing hormone on visceral fat, metabolic, and cardiovascular indices in human studies.
2015,
Pubmed
Surhio,
Antihyperlipidemic and hepatoprotective properties of selenium modified polysaccharide from Lachnum sp.
2017,
Pubmed
Taniguchi,
NF-κB, inflammation, immunity and cancer: coming of age.
2018,
Pubmed
Vekic,
Obesity and dyslipidemia.
2019,
Pubmed
Vetvicka,
Effects of yeast-derived beta-glucans on blood cholesterol and macrophage functionality.
2009,
Pubmed
Wang,
Marine polysaccharides attenuate metabolic syndrome by fermentation products and altering gut microbiota: An overview.
2018,
Pubmed
Wang,
Polygonatum odoratum Polysaccharides Modulate Gut Microbiota and Mitigate Experimentally Induced Obesity in Rats.
2018,
Pubmed
Wang,
Fucoidan from sea cucumber may improve hepatic inflammatory response and insulin resistance in mice.
2016,
Pubmed
,
Echinobase
Xia,
Structural characteristics and hepatoprotective potential of Aralia elata root bark polysaccharides and their effects on SCFAs produced by intestinal flora metabolism.
2019,
Pubmed
Xu,
The Role of PPAR and Its Cross-Talk with CAR and LXR in Obesity and Atherosclerosis.
2018,
Pubmed
Yadav,
Role of leptin and adiponectin in insulin resistance.
2013,
Pubmed
Yan,
Intake of total saponins and polysaccharides from Polygonatum kingianum affects the gut microbiota in diabetic rats.
2017,
Pubmed
Yang,
Effects of Cyclocarya paliurus polysaccharide on lipid metabolism-related genes DNA methylation in rats.
2019,
Pubmed
Zhang,
Acidic mucopolysaccharide from Holothuria leucospilota has antitumor effect by inhibiting angiogenesis and tumor cell invasion in vivo and in vitro.
2009,
Pubmed
,
Echinobase
Zhou,
Anti-atherosclerosis of oligomeric proanthocyanidins from Rhodiola rosea on rat model via hypolipemic, antioxidant, anti-inflammatory activities together with regulation of endothelial function.
2018,
Pubmed
Zhou,
The effect of di-2-ethylhexyl phthalate on inflammation and lipid metabolic disorder in rats.
2019,
Pubmed
Zhu,
Sulfated polysaccharide from sea cucumber modulates the gut microbiota and its metabolites in normal mice.
2018,
Pubmed
,
Echinobase
