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Mar Drugs
2019 Aug 28;179:. doi: 10.3390/md17090501.
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Echinochrome A Attenuates Cerebral Ischemic Injury through Regulation of Cell Survival after Middle Cerebral Artery Occlusion in Rat.
Kim R
,
Hur D
,
Kim HK
,
Han J
,
Mishchenko NP
,
Fedoreyev SA
,
Stonik VA
,
Chang W
.
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Of late, researchers have taken interest in alternative medicines for the treatment of brain ischemic stroke, where full recovery is rarely seen despite advanced medical technologies. Due to its antioxidant activity, Echinochrome A (Ech A), a natural compound found in sea urchins, has acquired attention as an alternative clinical trial source for the treatment of ischemic stroke. The current study demonstrates considerable potential of Ech A as a medication for cerebral ischemic injury. To confirm the effects of Ech A on the recovery of the injured region and behavioral decline, Ech A was administered through the external carotid artery in a rat middle cerebral artery occlusion model after reperfusion. The expression level of cell viability-related factors was also examined to confirm the mechanism of brain physiological restoration. Based on the results obtained, we propose that Ech A ameliorates the physiological deterioration by its antioxidant effect which plays a protective role against cell death, subsequent to post cerebral ischemic stroke.
Figure 3. Ech A treatment in cerebral injured brain alters the expression levels of cell viability-related factors. (A) The protein expression levels of cell survival and death regulators, such as Bcl-2, caspase-3, and Bax. (B) The protein expression levels of key players in vital cellular function regulation pathways, such as ERK and AKT. (C) The mRNA expression level of BDNF, supporting cell survival alteration in the injured brain region (* p < 0.05).
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