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Vet World
2019 May 01;125:684-688. doi: 10.14202/vetworld.2019.684-688.
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Golden sea cucumber extract revives glucose transporter-4 and interleukin-6 protein level in diabetic mouse muscle.
Purwanto B
,
Wiyasihati SI
,
Masyitha PA
,
Wigati KW
,
Irwadi I
.
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Background: Streptozotocin (STZ)-induced free radical oxidant activity resulted in muscle wasting due to protein carbonyl (PC), glucose transporter-4 (Glut-4), and interleukin-6 (IL-6) protein alteration. Antioxidant ingredient in the golden sea cucumber extract was found in promising level to inhibit free radical activity.
Aim: This study was aimed to investigate the effect of golden sea cucumber extract on PC, IL-6, and Glut-4 level of STZ-induced diabetes mouse.
Materials and Methods: This study was performed using mice, which were grouped into non-diabetes, diabetes, and diabetes-treated extract groups. The golden sea cucumber was extracted using 70% ethanol, which was administered by oral gavage twice a day for 5 consecutive days.
Results: The extract reduced PC level and improved muscle Glut-4 and IL-6 protein level of diabetic mouse.
Conclusion: The extract of golden sea cucumber revived muscle Glut-4 and IL-6 protein level in protection against muscle wasting.
Figure-1. (a-c) protein carbonyl, interleukin-6, and Glut-4 level in mg gastrocnemius muscletissue, comparison between groups. ND=Non-diabetes group, DM=Diabetes group, DM+extract=Diabetes extract-treated group. *Mean was significantly different to ND, #Mean was significantly different to DM. Error bar indicates standard error for each group.
Ceriello,
Antioxidant anti-inflammatory treatment in type 2 diabetes.
2009, Pubmed
Ceriello,
Antioxidant anti-inflammatory treatment in type 2 diabetes.
2009,
Pubmed
Cho,
IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045.
2018,
Pubmed
Diniz Vilela,
The Role of Metformin in Controlling Oxidative Stress in Muscle of Diabetic Rats.
2016,
Pubmed
Fu,
Effect and potential mechanism of action of sea cucumber saponins on postprandial blood glucose in mice.
2016,
Pubmed
,
Echinobase
Graham,
The streptozotocin-induced diabetic nude mouse model: differences between animals from different sources.
2011,
Pubmed
Johnston,
Streptozotocin induces G2 arrest in skeletal muscle myoblasts and impairs muscle growth in vivo.
2007,
Pubmed
Koksal,
Effect of Streptozotocin on Plasma Insulin Levels of Rats and Mice: A Meta-analysis Study.
2015,
Pubmed
Lima Leite,
Proteomic analysis of gastrocnemius muscle in rats with streptozotocin-induced diabetes and chronically exposed to fluoride.
2014,
Pubmed
Mohan,
Antidiabetic and Antioxidant Properties of Triticum aestivum in Streptozotocin-Induced Diabetic Rats.
2013,
Pubmed
Muñoz-Cánoves,
Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?
2013,
Pubmed
Perry,
Muscle atrophy in patients with Type 2 Diabetes Mellitus: roles of inflammatory pathways, physical activity and exercise.
2016,
Pubmed
Soewondo,
Challenges in diabetes management in Indonesia: a literature review.
2013,
Pubmed