ECB-ART-47329Vet World May 1, 2019; 12 (5): 684-688.
Golden sea cucumber extract revives glucose transporter-4 and interleukin-6 protein level in diabetic mouse muscle.
Background: Streptozotocin (STZ)-induced free radical oxidant activity resulted in muscle wasting due to protein carbonyl (PC), glucose transporter-4 (Glut-4), and interleukin-6 (IL-6) protein alteration. Antioxidant ingredient in the golden sea cucumber extract was found in promising level to inhibit free radical activity. Aim: This study was aimed to investigate the effect of golden sea cucumber extract on PC, IL-6, and Glut-4 level of STZ-induced diabetes mouse. Materials and Methods: This study was performed using mice, which were grouped into non-diabetes, diabetes, and diabetes-treated extract groups. The golden sea cucumber was extracted using 70% ethanol, which was administered by oral gavage twice a day for 5 consecutive days. Results: The extract reduced PC level and improved muscle Glut-4 and IL-6 protein level of diabetic mouse. Conclusion: The extract of golden sea cucumber revived muscle Glut-4 and IL-6 protein level in protection against muscle wasting.
PubMed ID: 31327904
PMC ID: PMC6584863
Article link: Vet World
Genes referenced: aqr
Article Images: [+] show captions
|Figure-1. (a-c) protein carbonyl, interleukin-6, and Glut-4 level in mg gastrocnemius muscle tissue, comparison between groups. ND=Non-diabetes group, DM=Diabetes group, DM+extract=Diabetes extract-treated group. *Mean was significantly different to ND, #Mean was significantly different to DM. Error bar indicates standard error for each group.|
References [+] :
Ceriello A, Antioxidant anti-inflammatory treatment in type 2 diabetes. 2009, Pubmed