ECB-ART-47273
Fish Shellfish Immunol
2019 Sep 01;92:384-394. doi: 10.1016/j.fsi.2019.06.017.
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Stress and immune response to bacterial LPS in the sea urchin Paracentrotus lividus (Lamarck, 1816).
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The immune system of the sea urchin species Paracentrotus lividus is highly complex and, as yet, poorly understood. P. lividus coelomocytes mediate immune response through phagocytosis and encapsulation of non-self particles, in addition to the production of antimicrobial molecules. Despite this understanding, details of exactly how these processes occur and the mechanisms which drive them are still in need of clarification. In this study, we show how the bacterial lipopolysaccharides (LPS) is able to induce a stress response which increases the levels of the heat shock proteins HSP70 and HSP90 only a few hours after treatment. This study also shows that LPS treatment increases the expression of the β-thymosin-derivated protein paracentrin, the precursor of antimicrobial peptides.
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Genes referenced: iqgap1 LOC100887844 LOC105439191 LOC115929188 LOC373484