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J R Soc Interface
2019 Mar 29;16152:20180668. doi: 10.1098/rsif.2018.0668.
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Flagellar ultrastructure suppresses buckling instabilities and enables mammalian sperm navigation in high-viscosity media.
Gadêlha H
,
Gaffney EA
.
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Eukaryotic flagellar swimming is driven by a slender motile unit, the axoneme, which possesses an internal structure that is essentially conserved in a tremendous diversity of sperm. Mammalian sperm, however, which are internal fertilizers, also exhibit distinctive accessory structures that further dress the axoneme and alter its mechanical response. This raises the following two fundamental questions. What is the functional significance of these structures? How do they affect the flagellar waveform and ultimately cell swimming? Hence we build on previous work to develop a mathematical mechanical model of a virtual human sperm to examine the impact of mammalian sperm accessory structures on flagellar dynamics and motility. Our findings demonstrate that the accessory structures reinforce the flagellum, preventing waveform compression and symmetry-breaking buckling instabilities when the viscosity of the surrounding medium is increased. This is in agreement with previous observations of internal and external fertilizers, such as human and sea urchin spermatozoa. In turn, possession of accessory structures entails that the progressive motion during a flagellar beat cycle can be enhanced as viscosity is increased within physiological bounds. Hence the flagella of internal fertilizers, complete with accessory structures, are predicted to be advantageous in viscous physiological media compared with watery media for the fundamental role of delivering a genetic payload to the egg.
Baltz,
Dense fibers protect mammalian sperm against damage.
1990,
Pubmed
,
Echinobase
Bayly,
Equations of interdoublet separation during flagella motion reveal mechanisms of wave propagation and instability.
2014,
Pubmed
Bayly,
Analysis of unstable modes distinguishes mathematical models of flagellar motion.
2015,
Pubmed
Becker,
Instability of elastic filaments in shear flow yields first-normal-stress differences.
2001,
Pubmed
Bedford,
Changes in -S-S- linked structures of the sperm tail during epididymal maturation, with comparative observations in sub-mammalian species.
1974,
Pubmed
Bourdieu,
Spiral defects in motility assays: A measure of motor protein force.
1995,
Pubmed
Brokaw,
Molecular mechanism for oscillation in flagella and muscle.
1975,
Pubmed
Brokaw,
Bend propagation by a sliding filament model for flagella.
1971,
Pubmed
Brokaw,
Thinking about flagellar oscillation.
2009,
Pubmed
Chopin,
Dynamic Wrinkling and Strengthening of an Elastic Filament in a Viscous Fluid.
2017,
Pubmed
Coy,
The counterbend dynamics of cross-linked filament bundles and flagella.
2017,
Pubmed
De Canio,
Spontaneous oscillations of elastic filaments induced by molecular motors.
2017,
Pubmed
Fawcett,
The mammalian spermatozoon.
1975,
Pubmed
Friedrich,
High-precision tracking of sperm swimming fine structure provides strong test of resistive force theory.
2010,
Pubmed
Fu,
Beating patterns of filaments in viscoelastic fluids.
2008,
Pubmed
Gadêlha,
Nonlinear instability in flagellar dynamics: a novel modulation mechanism in sperm migration?
2010,
Pubmed
Goldstein,
Elastohydrodynamic Synchronization of Adjacent Beating Flagella.
2016,
Pubmed
Goldstein,
Nonlinear dynamics of stiff polymers.
1995,
Pubmed
Gueron,
Simulations of three-dimensional ciliary beats and cilia interactions.
1993,
Pubmed
Hilfinger,
The chirality of ciliary beats.
2008,
Pubmed
Hilfinger,
Nonlinear dynamics of cilia and flagella.
2009,
Pubmed
Hines,
Bend propagation in flagella. I. Derivation of equations of motion and their simulation.
1978,
Pubmed
Ishimoto,
Coarse-Graining the Fluid Flow around a Human Sperm.
2017,
Pubmed
Ishimoto,
Human sperm swimming in a high viscosity mucus analogue.
2018,
Pubmed
Jawed,
Propulsion and Instability of a Flexible Helical Rod Rotating in a Viscous Fluid.
2015,
Pubmed
Johnson,
Flagellar hydrodynamics. A comparison between resistive-force theory and slender-body theory.
1979,
Pubmed
Kantsler,
Fluctuations, dynamics, and the stretch-coil transition of single actin filaments in extensional flows.
2012,
Pubmed
Kirkman-Brown,
Sperm motility: is viscosity fundamental to progress?
2011,
Pubmed
Lesich,
Insights into the mechanism of ADP action on flagellar motility derived from studies on bull sperm.
2008,
Pubmed
Lindemann,
Functional significance of the outer dense fibers of mammalian sperm examined by computer simulations with the geometric clutch model.
1996,
Pubmed
Lindemann,
"Geometric clutch" hypothesis of axonemal function: key issues and testable predictions.
1995,
Pubmed
Lindemann,
The stiffness of the flagella of impaled bull sperm.
1973,
Pubmed
Lindemann,
A model of flagellar and ciliary functioning which uses the forces transverse to the axoneme as the regulator of dynein activation.
1994,
Pubmed
Minoura,
Direct measurement of inter-doublet elasticity in flagellar axonemes.
1999,
Pubmed
Mitchison,
Cell biology: How cilia beat.
2010,
Pubmed
Montenegro-Johnson,
Spermatozoa scattering by a microchannel feature: an elastohydrodynamic model.
2015,
Pubmed
Moreau,
The asymptotic coarse-graining formulation of slender-rods, bio-filaments and flagella.
2018,
Pubmed
Okuno,
Inhibition and relaxation of sea urchin sperm flagella by vanadate.
1980,
Pubmed
,
Echinobase
Olson,
Observations of the structural components of flagellar axonemes and central pair microtubules from rat sperm.
1977,
Pubmed
Olson,
Coupling biochemistry and hydrodynamics captures hyperactivated sperm motility in a simple flagellar model.
2011,
Pubmed
Olson,
Structural chemistry of outer dense fibers of rat sperm.
1980,
Pubmed
Riedel-Kruse,
How molecular motors shape the flagellar beat.
2007,
Pubmed
Rikmenspoel,
The tail movement of bull spermatozoa. Observations and model calculations.
1965,
Pubmed
Saggiorato,
Human sperm steer with second harmonics of the flagellar beat.
2017,
Pubmed
Sakakibara,
Inner-arm dynein c of Chlamydomonas flagella is a single-headed processive motor.
1999,
Pubmed
Schmitz-Lesich,
Direct measurement of the passive stiffness of rat sperm and implications to the mechanism of the calcium response.
2004,
Pubmed
Schoeller,
From flagellar undulations to collective motion: predicting the dynamics of sperm suspensions.
2018,
Pubmed
Smith,
Bend propagation in the flagella of migrating human sperm, and its modulation by viscosity.
2009,
Pubmed
Toba,
Overlapping hand-over-hand mechanism of single molecular motility of cytoplasmic dynein.
2006,
Pubmed
Wiggins,
Trapping and wiggling: elastohydrodynamics of driven microfilaments.
1998,
Pubmed
Wolf,
Human cervical mucus. I. Rheologic characteristics.
1977,
Pubmed
Wolf,
Human cervical mucus. II. Changes in viscoelasticity during the ovulatory menstrual cycle.
1977,
Pubmed
Wolgemuth,
Twirling and whirling: viscous dynamics of rotating elastic filaments.
2000,
Pubmed
Woolley,
A study of helical and planar waves on sea urchin sperm flagella, with a theory of how they are generated.
2001,
Pubmed
,
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