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Mar Drugs
2019 Mar 07;173:. doi: 10.3390/md17030156.
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Preparation and Evaluation of Release Formulation of γ-Oryzanol/Algae Oil Self-Emulsified with Alginate Beads.
Yang KM
,
Chiang PY
.
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Self-emulsion improves solubility and bioavailability for γ-oryzanol/algae oil, and alginate beads can be used as controlled release carriers. In this study, self-emulsified alginate beads (SEABs) were prepared with different weight ratios of self-emulsion treatment (5%, 10%, 15%, 20%, and 30%) with alginate. We found that the microstructure with a surfactant of SEABs had a different appearance with alginate-based beads. The encapsulation of γ-oryzanol corresponded with the self-emulsion/alginate ratio, which was 98.93~60.20% with a different formulation of SEABs. During in vitro release, SEABs had the gastric protection of γ-oryzanol/algae oil, because γ-oryzanol and emulsion were not released in the simulated stomach fluid. When the SEABs were transferred to a simulation of the small intestine, they quickly began to swell and dissolve, releasing a higher content of the emulsion. We observed that the emulsion that formed had a bimodal distribution in the simulated intestinal fluid as a result of the hydrogel and emulsion droplets, leading to the formation of large aggregates. These results suggested that γ-oryzanol encapsulation within alginate beads via emulsification combined with gelation can serve as an effective controlled delivery system.
Figure 1. Photographic images of γ-oryzanol/algae oil self-emulsified alginate beads (SEABs) with different formulations.
Figure 2. SEM micrographs of SEABs in (a) non-self-emulsified, (b) 5% SEAB, (c) 10% SEAB, (g) 15% SEAB, (h) 20% SEAB, and (i) 30% SEAB forms, at 100× magnification. SEM micrographs of SEABs in (d) non-self-emulsified, (e) 5% SEAB, (f) 10% SEAB, (j) 15% SEAB, (k) 20% SEAB, and (l) 30% SEAB forms, at 5000× magnification.
Figure 3. The release of γ- oryzanol/algae oil SEABs in simulated stomach fluid: (A) γ-oryzanol and (B) 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging.
Figure 4. The release of γ- oryzanol/algae oil SEABs in the simulated intestinal fluid.
Figure 5. Graphical abstract of γ-oryzanol SEAB release in simulated intestinal fluid.
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