ECB-ART-46751
Nat Prod Commun
2017 Feb 01;122:261-262.
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Isolation and Characterization of Antiangiogenesis Compounds from the Fungus Aspergillus terreus Associated with Apostichopus japonicus Using Zebrafish Assay.
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Three compouds, (+)-butyrolactone IV (1), butyrolactone I (2) and terrelactone A (3) were isolated from the fungus Aspergillus terreus associated with Apostichopusjaponicus from the Yellow Sea in China; their structures were elucidated by spectral methods. Compounds I and 2 were shown to have moderate antiangiogenesis activity when tested using-the zebrafish assay. This is the first report of butyrolactones with antiangiogenesis activity.
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Genes referenced: LOC100887844