Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Environ Monit Assess
2018 Aug 07;1909:502. doi: 10.1007/s10661-018-6808-y.
Show Gene links
Show Anatomy links
Low-dose action of tryptanthrin and its derivatives against developing embryos of the sea urchin Strongylocentrotus intermedius.
Agafonova IG
,
Moskovkina TV
.
???displayArticle.abstract???
Nine tryptanthrin derivatives, including tryptanthrin itself, were synthesized using different methods, including oxidation of the corresponding isatins to obtain 1-4, the reaction of tryptanthrin 1 with hydrazine and its derivatives to obtain 5-7, and aldol condensation of 1 with acetone and methylethylketone to obtain 8 and 9. The action of 1-9 in doses corresponding to the IC50 against developing embryos of the sea urchin Strongylocentrotus intermedius and in the sperm test allowed us to estimate to potency of all the compounds and to determine which were cytotoxic. In addition, these studies showed that compounds 3, 4, 8, and 9 had a stimulatory effect at lower doses. In particular, the tryptanthrin derivatives stimulated the larval stages of development in surviving embryos at concentrations lower than the IC50.
Brufani,
The structure of tryptanthrin.
1971, Pubmed
Brufani,
The structure of tryptanthrin.
1971,
Pubmed
Buznikov,
Nicotinic antagonists (piperidines and quinuclidines) reduce the susceptibility of early sea urchin embryos to agents evoking calcium shock.
1997,
Pubmed
,
Echinobase
Buznikov,
From oocyte to neuron: do neurotransmitters function in the same way throughout development?
1996,
Pubmed
Chiang,
An in vitro study of the antimicrobial effects of indigo naturalis prepared from Strobilanthes formosanus Moore.
2013,
Pubmed
El-Gendy,
Bioactive benzopyrone derivatives from new recombinant fusant of marine Streptomyces.
2008,
Pubmed
Hamaguchi,
Effects of the phosphatase inhibitors, okadaic acid, ATPgammaS, and calyculin A on the dividing sand dollar egg.
2002,
Pubmed
,
Echinobase
Han,
Tryptanthrin ameliorates atopic dermatitis through down-regulation of TSLP.
2014,
Pubmed
Honda,
The antimicrobial specificity of tryptanthrin.
1979,
Pubmed
Hwang,
Design, synthesis, and structure-activity relationship studies of tryptanthrins as antitubercular agents.
2013,
Pubmed
Ishihara,
Tryptanthrin inhibits nitric oxide and prostaglandin E(2) synthesis by murine macrophages.
2000,
Pubmed
Jao,
Isolation, structure elucidation, and synthesis of cytotoxic tryptanthrin analogues from Phaius mishmensis.
2008,
Pubmed
Kiselev,
What can we learn about the lipid vesicle structure from the small-angle neutron scattering experiment?
2006,
Pubmed
Kiselev,
Properties of ternary phospholipid/dimethyl sulfoxide/water systems at low temperatures.
2005,
Pubmed
Koya-Miyata,
Prevention of azoxymethane-induced intestinal tumors by a crude ethyl acetate-extract and tryptanthrin extracted from Polygonum tinctorium Lour.
2001,
Pubmed
Lin,
Indigo naturalis upregulates claudin-1 expression in human keratinocytes and psoriatic lesions.
2013,
Pubmed
Mitscher,
Tuberculosis: a search for novel therapy starting with natural products.
1998,
Pubmed
Pergola,
On the inhibition of 5-lipoxygenase product formation by tryptanthrin: mechanistic studies and efficacy in vivo.
2012,
Pubmed
Rasmussen,
Phase diagram for the system water-dimethylsulphoxide.
1968,
Pubmed
Schindler,
[Metabolic products of microorganisms. 91. Tryptanthrin, a tryptophan derived antibiotic from Candida lipolytica].
1971,
Pubmed
Shaaban,
Pharacine, a natural p-cyclophane and other indole derivatives from Cytophaga sp. strain AM13.1.
2002,
Pubmed
Shim,
Comparative toxicities of organotin compounds on fertilization and development of sea urchin (Anthocidaris crassispina).
2006,
Pubmed
,
Echinobase
Srivastava,
A review on phytochemical, pharmacological, and pharmacognostical profile of Wrightia tinctoria: Adulterant of kurchi.
2014,
Pubmed
Wagner-Döbler,
Oceanibulbus indolifex gen. nov., sp. nov., a North Sea alphaproteobacterium that produces bioactive metabolites.
2004,
Pubmed
