Angew Chem Int Ed Engl 2018 Jul 02;5727:8043-8047. doi: 10.1002/anie.201802833.

Emulsion-Assisted Polymerization-Induced Hierarchical Self-Assembly of Giant Sea Urchin-like Aggregates on a Large Scale.

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Hierarchical solution self-assembly has become an important biomimetic method to prepare highly complex and multifunctional supramolecular structures. However, despite great progress, it is still highly challenging to prepare hierarchical self-assemblies on a large scale because the self-assembly processes are generally performed at high dilution. Now, an emulsion-assisted polymerization-induced self-assembly (EAPISA) method with the advantages of in situ self-assembly, scalable preparation, and facile functionalization was used to prepare hierarchical multiscale sea urchin-like aggregates (SUAs). The obtained SUAs from amphiphilic alternating copolymers have a micrometer-sized rattan ball-like capsule (RBC) acting as the hollow core body and radiating nanotubes tens of micrometers in length as the hollow spines. They can capture model proteins effectively at an ultra-low concentration (ca. 10 nm) after functionalization with amino groups through click copolymerization.

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Genes referenced: LOC100887844 LOC115925415 tefl