Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Echinobase
ECB-ART-46090
Einstein (Sao Paulo) 2017 Jan 01;154:441-444. doi: 10.1590/S1679-45082017AO4012.
Show Gene links Show Anatomy links

Urinary beta-trace protein gene expression analysis in type 2 diabetes mellitus patients.

Bacci MR , Alves BDCA , Cavallari MR , Azzalis LA , Rozier-Alves RM , Perez MM , Chehter EZ , Pereira EC , Fonseca FLA .


???displayArticle.abstract???
OBJECTIVE: To evaluate the gene expression of beta-trace protein in urine of diabetic patients, with no reduction in glomerular filtration rate, which was defined as below 60mL/min/1.73m2. METHODS: Type 2 diabetes mellitus patients were recruited, and a group of non-diabetic individuals served as control. Beta-trace protein gene expression was analyzed by quantitative PCR. Blood samples were collected to establish glucose levels and baseline kidney function. Accuracy was analyzed using ROC curves. RESULTS: Ninety type 2 diabetes mellitus patients and 20 non-diabetic individuals were recruited. The area under the curve was 0.601, sensitivity of 20% and specificity of 89.47%. Among diabetic participants, 18% showed an expression above the cutoff point. CONCLUSION: These results of accuracy of beta-trace protein gene expression in urine of diabetic patients are promising, although they did not achieve a higher area under the curve level.

???displayArticle.pubmedLink??? 29364366
???displayArticle.pmcLink??? PMC5875157
???displayArticle.link??? Einstein (Sao Paulo)



References [+] :
Bacci, The impact of lipocalin-type-prostaglandin-D-synthase as a predictor of kidney disease in patients with type 2 diabetes. 2015, Pubmed