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Chronobiol Int
2018 Feb 01;352:147-159. doi: 10.1080/07420528.2017.1388253.
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Repercussions of hypo and hyperthyroidism on the heart circadian clock.
Peliciari-Garcia RA
,
Bargi-Souza P
,
Young ME
,
Nunes MT
.
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Myocardial gene expression and metabolism fluctuate over the course of the day in association with changes in energy supply and demand. Time-of-day-dependent oscillations in myocardial processes have been linked to the intrinsic cardiomyocyte circadian clock. Triiodothyronine (T3) is an important modulator of heart metabolism and function. Recently, our group has reported time-of-day-dependent rhythms in cardiac T3 sensitivity, as well as, T3-mediated acute alterations on core clock components. Hypo and hyperthyroidism are the second most prevalent endocrine disease worldwide. Considering the importance of the cardiomyocyte circadian clock and T3 to cardiac physiology, the aim of this study was to investigate the consequences of chronic hypo and hyperthyroidism on 24-h rhythms of circadian clock genes in the heart. Hypo and hyperthyroidism was induced in rats by thyroidectomy (Tx) and i.p. injections of supraphysiological dose of T3, respectively. Here we report alterations in mRNA levels of the major core clock components (Bmal1, Per2, Nr1d1, and Rora) for both experimental conditions (with the exception of Per2 during hyperthyroid condition). Oscillations in mRNA levels of key glucose and fatty-acid metabolism genes known to be clock controlled (Pdk4, Ucp3, Acot1, and Cd36) were equally affected by the experimental conditions, especially during the hypothyroid state. These findings suggest that chronic alterations in thyroid status significantly impacts 24-h rhythms in circadian clock and metabolic genes in the heart. Whether these perturbations contribute toward the pathogenesis of cardiac dysfunction associated with hypo and hyperthyroidism requires further elucidation.
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Ahlersová,
Circadian oscillations of serum thyroid hormones in the laboratory rat: the effect of photoperiods.
1997, Pubmed
Ahlersová,
Circadian oscillations of serum thyroid hormones in the laboratory rat: the effect of photoperiods.
1997,
Pubmed
Bargi-Souza,
Triiodothyronine rapidly alters the TSH content and the secretory granules distribution in male rat thyrotrophs by a cytoskeleton rearrangement-independent mechanism.
2013,
Pubmed
Benjamin,
Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association.
2017,
Pubmed
Biondi,
Hypothyroidism as a risk factor for cardiovascular disease.
2004,
Pubmed
Biondi,
Effects of thyroid hormone on cardiac function: the relative importance of heart rate, loading conditions, and myocardial contractility in the regulation of cardiac performance in human hyperthyroidism.
2002,
Pubmed
Bray,
Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression.
2008,
Pubmed
Campos-Barros,
Evidence for circadian variations of thyroid hormone concentrations and type II 5'-iodothyronine deiodinase activity in the rat central nervous system.
1997,
Pubmed
Cerbone,
Cardiovascular risk factors in children with long-standing untreated idiopathic subclinical hypothyroidism.
2014,
Pubmed
Chu,
Contribution of FSH and triiodothyronine to the development of circadian clocks during granulosa cell maturation.
2012,
Pubmed
Cornélissen,
Chronobiometry with pocket calculators and computer systems.
1980,
Pubmed
Danzi,
Thyroid hormone and the cardiovascular system.
2012,
Pubmed
Dillmann,
Editorial: thyroid hormone action and cardiac contractility - a complex affair.
1996,
Pubmed
Dillmann,
Cellular action of thyroid hormone on the heart.
2002,
Pubmed
Durgan,
The cardiomyocyte circadian clock: emerging roles in health and disease.
2010,
Pubmed
Durgan,
Evidence suggesting that the cardiomyocyte circadian clock modulates responsiveness of the heart to hypertrophic stimuli in mice.
2011,
Pubmed
Dussault,
Rapid and simple comparison of messenger RNA levels using real-time PCR.
2006,
Pubmed
Emery,
A rhythmic Ror.
2004,
Pubmed
Fahrenkrug,
Hypophysectomy abolishes rhythms in rat thyroid hormones but not in the thyroid clock.
2017,
Pubmed
Floriani,
Subclinical thyroid dysfunction and cardiovascular diseases: 2016 update.
2018,
Pubmed
Guo,
Alterations of the daily rhythms of HPT axis induced by chronic unpredicted mild stress in rats.
2015,
Pubmed
Hak,
Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study.
2000,
Pubmed
Jabbar,
Thyroid hormones and cardiovascular disease.
2017,
Pubmed
Jordan,
Evidence for circadian variations in serum thyrotropin, 3,5,3'-triiodothyronine, and thyroxine in the rat.
1980,
Pubmed
Klein,
Thyroid hormone and the cardiovascular system.
2001,
Pubmed
Kovac,
A time to fast, a time to feast: the crosstalk between metabolism and the circadian clock.
2009,
Pubmed
Kuno-Murata,
Augmentation of thyroid hormone receptor-mediated transcription by Ca2+/calmodulin-dependent protein kinase type IV.
2000,
Pubmed
Livak,
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
2001,
Pubmed
Lopaschuk,
Myocardial fatty acid metabolism in health and disease.
2010,
Pubmed
MacLennan,
Phospholamban: a crucial regulator of cardiac contractility.
2003,
Pubmed
Maia,
Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans.
2005,
Pubmed
Morkin,
Biochemical and physiologic effects of thyroid hormone on cardiac performance.
1983,
Pubmed
Mozaffarian,
Heart disease and stroke statistics--2015 update: a report from the American Heart Association.
2015,
Pubmed
Nelson,
Methods for cosinor-rhythmometry.
1979,
Pubmed
Nunes,
Thyroxine induced transformation in sarcoplasmic reticulum of rabbit soleus and psoas muscles.
1985,
Pubmed
Peliciari-Garcia,
Interrelationship between 3,5,3´-triiodothyronine and the circadian clock in the rodent heart.
2016,
Pubmed
,
Echinobase
Peliciari-Garcia,
Expression of circadian clock and melatonin receptors within cultured rat cardiomyocytes.
2011,
Pubmed
Rakov,
Sex-specific phenotypes of hyperthyroidism and hypothyroidism in mice.
2016,
Pubmed
Rohrer,
Thyroid hormone markedly increases the mRNA coding for sarcoplasmic reticulum Ca2+-ATPase in the rat heart.
1988,
Pubmed
Romano,
Hypothyroidism in adult male rats alters posttranscriptional mechanisms of luteinizing hormone biosynthesis.
2013,
Pubmed
Shibusawa,
Thyroid hormone receptor DNA binding is required for both positive and negative gene regulation.
2003,
Pubmed
Tadic,
Subclinical hyperthyroidism and biatrial function and mechanics: a two- and three-dimensional echocardiographic study.
2016,
Pubmed
Tadic,
How Does Subclinical Hyperthyroidism Affect Right Heart Function and Mechanics?
2016,
Pubmed
Takahashi,
Molecular components of the circadian clock in mammals.
2015,
Pubmed
Wangensteen,
Dietary salt restriction in hyperthyroid rats. Differential influence on left and right ventricular mass.
2015,
Pubmed
Yasuo,
Molecular mechanism of photoperiodic time measurement in the brain of Japanese quail.
2006,
Pubmed
Young,
Intrinsic diurnal variations in cardiac metabolism and contractile function.
2001,
Pubmed
Young,
Clock genes in the heart: characterization and attenuation with hypertrophy.
2001,
Pubmed
Young,
The circadian clock within the heart: potential influence on myocardial gene expression, metabolism, and function.
2006,
Pubmed