ECB-ART-39229
Biochem Soc Trans
2004 Dec 01;32Pt 6:1115-7. doi: 10.1042/BST0321115.
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What is in a filopodium? Starfish versus hedgehogs.
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Many cell types can generate thin actin-based protrusive structures, which are often classified under the general term of ''filopodia''. However, a range of filopodia-like structures exists that differ both morphologically and functionally. In this brief review, we discuss the different types of filopodial structures, together with the actin-binding proteins and signalling pathways involved in their formation. Specifically, we highlight the differences between the filopodial extensions induced by the Rho GTPases Cdc42 and Rif.
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Genes referenced: cdc42 LOC100893746 LOC115919910 LOC590297