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Antibody Name: LOC373178 Ab4 Common Name: kinesin heavy chain RRID: Synonyms: SUK4, kinesin family member 5B Antigens Gene: LOC373178 Clone Type: Monoclonal Source:

Antibody
Clone Number	SUK4
Purification	Affinity Purification
Isotype	IgG1
Host Organism	mouse
Echinoderm Reactivity	S. purpuratus, L. pictus
Non-Echinoderm Reactivity	cow, fruitfly
Description:	Function-blocking antibody that specifically binds to the head region (1-393) of a mitotic protein. Demonstrated to inhibit kinesin-mediated microtubule motility in vitro by binding to a ATP-sensitive motor domain. Created by Amie L. Ingold, Stanley A. Cohn, and Jonathan M. Scholey at the University of Colorado Health Science Center (PMID: 2974459) and characterized by the Scholey lab at the University of California in Davis (PMID: 1827446).
Immunogen
Name	ATP/EDTA Recycled Kinesin
Type	polypeptide
Post Translational Modifications	None
Source Organism	purple sea urchin
Description	Native 130-kD protein affinity-purified from microtubules extracted from sea urchin eggs.
Sequence
Reported Usage
immunohistochemistry
western blot
immunoprecipitation
immunofluorescence
enzyme-linked immunosorbent assay
Publications
???displayAntibody.papersFirst???	Inhibition of kinesin-driven microtubule motility by monoclonal antibodies to kinesin heavy chains., J Cell Biol 1988
???displayAntibody.papersRecent???	Heterotrimeric kinesin-II is required for the assembly of motile 9+2 ciliary axonemes on sea urchin embryos., J Cell Biol 1997
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