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Echinobase

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ECB-ANTIBODY-26395343

Antibody Name: LOC100888451 Ab2

Common Name: uncharacterized LOC100888451

RRID:
Synonyms: 4F7, Sp-Fsialin, flagellasialin, polySia-containing glycoprotein of sperm flagella

Antigens
Gene: LOC100888451

Clone Type: Monoclonal
Source:

Antibody
Clone Number 4F7
Purification
Isotype IgG
Host Organism mouse
Echinoderm Reactivity S. purpuratus, H. pulcherrimus
Non-Echinoderm Reactivity
Description: Specifically recognizes the ganglioside structure, a2,9-linked polyNeu5Ac, on a 40-80 kDa sperm glycoprotein. Demonstrated to inhibit sperm mobility in vitro. Created in the Kitajima lab at Nagoya University in Japan. Also reacts with Strongylocentrotus franciscanus.
Immunogen
Name Neisseria meningitidis Group C (NMGC) Cells
Type other immunogen type
Post Translational Modifications Glycosylation
Source Organism Other
Description Adherent cells from neuroinvasive strain expressing glycoproteins with a2,9-polySia linkages grown in chemically defined media.
Sequence
Reported Usage
western blot
Publications
???displayAntibody.papersFirst??? Flagellasialin: a novel sulfated alpha2,9-linked polysialic acid glycoprotein of sea urchin sperm flagella., Glycobiology 2006  
???displayAntibody.papersRecent??? Mechanism regulating Ca2+-dependent mechanosensory behaviour in sea urchin spermatozoa., Cell Struct Funct 2011  
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