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Peptide-directed synthesis of chiral nano-bipyramids for controllable antibacterial application.
Chen P
,
Wang G
,
Hao C
,
Ma W
,
Xu L
,
Kuang H
,
Xu C
,
Sun M
.
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The emergence of antibiotic resistance makes the therapeutic effect of traditional antibiotics far from satisfactory. Here, chiral gold nano-bipyramids (GBPs) with sea cucumber-like morphology are reported, and used in the fight against bacterial infection. Specifically, the dipeptide of d-/l-Cys-Phe (CF) caused the nano-bipyramids to form a spike shape with an optical anisotropy factor of 0.102 at 573 nm. The antibacterial effects showed that d-GBPs and l-GBPs could efficiently destroy bacteria with a death ratio of 98% and 70% in vitro. Also, both in vivo skin infection and sepsis models showed that the chiral GBPs could effectively promote wound healing and prevent sepsis in mice. Mechanistic studies showed that the binding affinity of d-GBPs (1.071 ± 0.023 × 108 M-1) was 12.39-fold higher than l-GBPs (8.664 ± 0.251 × 106 M-1) to protein A of Staphylococcus aureus, which caused further adsorption of d-GBPs onto the bacterial surface. Moreover, the physical destruction of the bacterial cell wall caused by the spike chiral GBPs, resulted in a stronger antibacterial effect for d-GBPs than l-GBPs. Furthermore, the excellent PTT of d-/l-GBPs further exacerbated the death of bacteria without any side-effect. Overall, chiral nano-bipyramids have opened a new avenue for improved antibacterial efficacy in the treatment of bacterial infections.
Agnes,
Helical Nanofibers Formed by Palladium-Mediated Assembly of Organic Homochiral Macrocycles Containing Binaphthyl and Pyridyl Units.
2021, Pubmed
Agnes,
Helical Nanofibers Formed by Palladium-Mediated Assembly of Organic Homochiral Macrocycles Containing Binaphthyl and Pyridyl Units.
2021,
Pubmed
Andersson,
Antibiotic resistance and its cost: is it possible to reverse resistance?
2010,
Pubmed
Caricato,
Nanostructuring with chirality: binaphthyl-based synthons for the production of functional oriented nanomaterials.
2014,
Pubmed
Chen,
Photoactivated Release of Nitric Oxide and Antimicrobial Peptide Derivatives for Synergistic Therapy of Bacterial Skin Abscesses.
2022,
Pubmed
Fang,
Differential Pd-nanocrystal facets demonstrate distinct antibacterial activity against Gram-positive and Gram-negative bacteria.
2018,
Pubmed
Feng,
Smart Asymmetric Hydrogel with Integrated Multi-Functions of NIR-Triggered Tunable Adhesion, Self-Deformation, and Bacterial Eradication.
2021,
Pubmed
Gao,
Surface-bound reactive oxygen species generating nanozymes for selective antibacterial action.
2021,
Pubmed
Hou,
Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis.
2020,
Pubmed
Hussain,
Antibiotic-loaded nanoparticles targeted to the site of infection enhance antibacterial efficacy.
2018,
Pubmed
Hwang,
Photobactericidal activity activated by thiolated gold nanoclusters at low flux levels of white light.
2020,
Pubmed
Jiang,
Hydrophilic nanoparticles that kill bacteria while sparing mammalian cells reveal the antibiotic role of nanostructures.
2022,
Pubmed
Koide,
Synthetic hydrogel nanoparticles for sepsis therapy.
2021,
Pubmed
Lee,
Amino-acid- and peptide-directed synthesis of chiral plasmonic gold nanoparticles.
2018,
Pubmed
Lee,
Bipyramid-templated synthesis of monodisperse anisotropic gold nanocrystals.
2015,
Pubmed
Li,
Zinc-doped Prussian blue enhances photothermal clearance of Staphylococcus aureus and promotes tissue repair in infected wounds.
2019,
Pubmed
Liang,
Ratiometric FRET Encoded Hierarchical ZrMOF @ Au Cluster for Ultrasensitive Quantifying MicroRNA In Vivo.
2022,
Pubmed
Linklater,
Antibacterial Action of Nanoparticles by Lethal Stretching of Bacterial Cell Membranes.
2020,
Pubmed
Liu,
Stabilizing Enzymes in Plasmonic Silk Film for Synergistic Therapy of In Situ SERS Identified Bacteria.
2022,
Pubmed
Long,
Hedgehog artificial macrophage with atomic-catalytic centers to combat Drug-resistant bacteria.
2021,
Pubmed
Longo,
Reversible chirality control in peptide-functionalized gold nanoparticles.
2013,
Pubmed
Peng,
Superparamagnetic nickel colloidal nanocrystal clusters with antibacterial activity and bacteria binding ability.
2018,
Pubmed
Qiao,
Treatment of MRSA-infected osteomyelitis using bacterial capturing, magnetically targeted composites with microwave-assisted bacterial killing.
2020,
Pubmed
Slocik,
Plasmonic circular dichroism of Peptide-functionalized gold nanoparticles.
2011,
Pubmed
Stabryla,
Role of bacterial motility in differential resistance mechanisms of silver nanoparticles and silver ions.
2021,
Pubmed
Sun,
Chiral Upconversion Heterodimers for Quantitative Analysis and Bioimaging of Antibiotic-Resistant Bacteria In Vivo.
2018,
Pubmed
Sánchez-Iglesias,
High-Yield Seeded Growth of Monodisperse Pentatwinned Gold Nanoparticles through Thermally Induced Seed Twinning.
2017,
Pubmed
Tian,
Water-Soluble Organic Nanoparticles with Programable Intermolecular Charge Transfer for NIR-II Photothermal Anti-Bacterial Therapy.
2021,
Pubmed
Wang,
Chiral Plasmonic Triangular Nanorings with SERS Activity for Ultrasensitive Detection of Amyloid Proteins in Alzheimer's Disease.
2021,
Pubmed
Wang,
Pretreated Macrophage-Membrane-Coated Gold Nanocages for Precise Drug Delivery for Treatment of Bacterial Infections.
2018,
Pubmed
Wang,
The Density of Surface Coating Can Contribute to Different Antibacterial Activities of Gold Nanoparticles.
2020,
Pubmed
Wang,
Graphdiyne-modified TiO2 nanofibers with osteoinductive and enhanced photocatalytic antibacterial activities to prevent implant infection.
2020,
Pubmed
Wang,
Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance.
2021,
Pubmed
Wu,
Reactivity Differences Enable ROS for Selective Ablation of Bacteria.
2022,
Pubmed
Wu,
Bifunctional Gold Nanobipyramids for Photothermal Therapy and Temperature Monitoring.
2019,
Pubmed
Xin,
Chiral Nanoparticle as a New Efficient Antimicrobial Nanoagent.
2017,
Pubmed
Yuwen,
MoS2@polydopamine-Ag nanosheets with enhanced antibacterial activity for effective treatment of Staphylococcus aureus biofilms and wound infection.
2018,
Pubmed
Zhang,
Bioresponsive Nanoparticles Targeted to Infectious Microenvironments for Sepsis Management.
2018,
Pubmed
Zhang,
Extracellular vesicles based self-grown gold nanopopcorn for combinatorial chemo-photothermal therapy.
2019,
Pubmed
Zhang,
Photon-Responsive Antibacterial Nanoplatform for Synergistic Photothermal-/Pharmaco-Therapy of Skin Infection.
2019,
Pubmed
Zhang,
Prescribing Silver Chirality with DNA Origami.
2021,
Pubmed
Zhao,
Surface-kinetics mediated mesoporous multipods for enhanced bacterial adhesion and inhibition.
2019,
Pubmed
