Guryanova SV , Ovchinnikova TV .

22-14-00380 Russian Science Foundation

	Figure 1. Structures of TLRs. Leucine-rich repeat extracellular domain (LRR), membrane spanning transmembrane domain (MB), and cytoplasmic domain (TIR). LRR domains containing cysteine residues in the C-terminal part (LRRCT) are depicted as yellow triangles. LRR domains containing cysteine residues in the N-terminal part (LRRNT) are depicted as pink triangles. V-type TLRs have only one LRRCT (single cysteine cluster) located next to the TIR domain; P-type TLRs have more than one LRRCT and sometimes an LRRNT (multiple cysteine cluster) domain.
	Figure 2. NLR family. The NLR family is subdivided into the following four subgroups: NLRA, NLRB, NLRC, and NLRP, depending on the nature of the N-terminal domain, consisting of the transactivation domain (AD), the baculovirus IAP repeat (BIR), the caspase activation and recruitment domain (CARD), and the pyrine domain, respectively. (PYD). The FIND domain is also present in NLRP1. PYD and CARD are death domains (DD) that appear to mediate homotypic domain interactions. LRR domains represented as circles.
	Figure 3. RIG-I-like receptor (retinoic acid-inducible gene-I-like receptors, RLRs) family: retinoic-acid inducible gene 1 (RIG-I), laboratory of genetics and physiology 2 (LGP2); melanoma differentiation-associated 5 (MDA5). All RLRs have a central helicase domain. C-terminal domain (CTD) and the caspase activation and recruitment domain (CARD) may be also present.
	Figure 4. C-type lectin receptors (CLRs). Soluble CLRs have several carbohydrate recognition domains (CRDs) and have no transmembrane domain. Type I CLRs include several CRD or CRD-like domains, transmembrane and cytoplasmic domains. Type II CLRs have one CRD, transmembrane and different cytoplasmic domains.

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