Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Sea Cucumber Compounds Targeting NF-κB in Cancer Treatment.
Wargasetia TL
,
Ratnawati H
,
Widodo N
.
???displayArticle.abstract???
Cancer is a major health problem worldwide and the leading cause of death in many countries. It remains challenging to find anticancer treatments that work efficiently for varying types of cancer cells. Several studies revealed that nuclear factor kappa B (NF-κB) is a family of dimeric transcription factors that induce tumor promotion, progression, and therapeutic resistance, providing evidence that NF-kB may be a promising target for cancer drugs. Some research has found that sea cucumber biocompounds have anticancer properties, but further research is essential to confirm anticancer targets. This manuscript discusses the mechanisms of anticancer targeting the NF-κB signaling pathway induced by sea cucumber-derived compounds. Additional database analysis showed the protein targeted by the compounds involved in several pathways related to the NF-κB network. Moreover, SwissADME predicted druglikeliness properties of the active compounds of sea cucumber. The discussion is expected to provide new insight into the promising potential of these marine natural products for the treatment of many different types of cancers.
Figure 1. Sea cucumber active compounds (green font) might intervene cancer cell growth through EGFR-Pi3 K/AKT dependent NF-κB pathway. The Illustration was Created with BioRender.com application.
Al-Nour,
Ellagic Acid, Kaempferol, and Quercetin from Acacia nilotica: Promising Combined Drug With Multiple Mechanisms of Action.
2019, Pubmed
Al-Nour,
Ellagic Acid, Kaempferol, and Quercetin from Acacia nilotica: Promising Combined Drug With Multiple Mechanisms of Action.
2019,
Pubmed
Balkwill,
Inflammation and cancer: back to Virchow?
2001,
Pubmed
Ballard,
The v-rel oncogene encodes a kappa B enhancer binding protein that inhibits NF-kappa B function.
1990,
Pubmed
Careaga,
Antiproliferative, cytotoxic and hemolytic activities of a triterpene glycoside from Psolus patagonicus and its desulfated analog.
2009,
Pubmed
,
Echinobase
Chaturvedi,
NF-κB addiction and its role in cancer: 'one size does not fit all'.
2011,
Pubmed
Daina,
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules.
2017,
Pubmed
Dąbek,
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB): a new potential therapeutic target in atherosclerosis?
2010,
Pubmed
Erstad,
Targeting the NF-κB pathway in cancer therapy.
2013,
Pubmed
Fedorov,
In vitro Anticancer Activities of Some Triterpene Glycosides from Holothurians of Cucumariidae, Stichopodidae, Psolidae, Holothuriidae and Synaptidae families.
2016,
Pubmed
,
Echinobase
Feng,
The drug likeness analysis of anti-inflammatory clerodane diterpenoids.
2020,
Pubmed
Gambhir,
Nuclear factor kappa B role in inflammation associated gastrointestinal malignancies.
2015,
Pubmed
Hitchcock,
Structure-brain exposure relationships.
2006,
Pubmed
Holohan,
Cancer drug resistance: an evolving paradigm.
2013,
Pubmed
Jain,
Insights into the mechanism of natural terpenoids as NF-κB inhibitors: an overview on their anticancer potential.
2016,
Pubmed
Jing,
NF-κB in cellular senescence and cancer treatment.
2014,
Pubmed
Li,
NF-κB in cancer therapy.
2015,
Pubmed
Lin,
The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapy.
2010,
Pubmed
Lipinski,
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.
2001,
Pubmed
Mitchell,
Signaling via the NFκB system.
2016,
Pubmed
Mokgautsi,
Network Pharmacological Analysis through a Bioinformatics Approach of Novel NSC765600 and NSC765691 Compounds as Potential Inhibitors of CCND1/CDK4/PLK1/CD44 in Cancer Types.
2021,
Pubmed
Moretti,
Cancer: NF-κB regulates energy metabolism.
2012,
Pubmed
Nair,
Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion.
2006,
Pubmed
Nazemi,
Cytotoxicity Activity and Druggability Studies of Sigmasterol Isolated from Marine Sponge Dysidea avara Against Oral Epithelial Cancer Cell (KB/C152) and T-Lymphocytic Leukemia Cell Line (Jurkat/ E6-1).
2020,
Pubmed
Oduselu,
Homology Modelling and Molecular Docking Studies of Selected Substituted Benzo[d]imidazol-1-yl)methyl)benzimidamide Scaffolds on Plasmodium falciparum Adenylosuccinate Lyase Receptor.
2019,
Pubmed
Pajouhesh,
Medicinal chemical properties of successful central nervous system drugs.
2005,
Pubmed
Park,
Frondoside A has an anti-invasive effect by inhibiting TPA-induced MMP-9 activation via NF-κB and AP-1 signaling in human breast cancer cells.
2012,
Pubmed
Silchenko,
Constituents of the sea cucumber Cucumaria okhotensis. Structures of okhotosides B1-B3 and cytotoxic activities of some glycosides from this species.
2008,
Pubmed
,
Echinobase
Tylińska,
Novel Pyrimidine Derivatives as Potential Anticancer Agents: Synthesis, Biological Evaluation and Molecular Docking Study.
2021,
Pubmed
Verheij,
Leadlikeness and structural diversity of synthetic screening libraries.
2006,
Pubmed
Wargasetia,
Potential use of compounds from sea cucumbers as MDM2 and CXCR4 inhibitors to control cancer cell growth.
2018,
Pubmed
,
Echinobase
Xia,
NF-κB, an active player in human cancers.
2014,
Pubmed
Zhao,
In vitro and in vivo anti-tumour activities of echinoside A and ds-echinoside A from Pearsonothuria graeffei.
2012,
Pubmed
,
Echinobase
Zhao,
Ds-echinoside A, a new triterpene glycoside derived from sea cucumber, exhibits antimetastatic activity via the inhibition of NF-κB-dependent MMP-9 and VEGF expressions.
2011,
Pubmed
,
Echinobase
Zhao,
Differential effects of sulfated triterpene glycosides, holothurin A1, and 24-dehydroechinoside A, on antimetastasic activity via regulation of the MMP-9 signal pathway.
2010,
Pubmed
,
Echinobase
