Chatterjee S and Sil PC (2022), ROS-Influenced Regulatory Cross-Talk With Wnt S...

ECB-ART-50346

Front Mol Biosci 2022 Apr 19;9:889719. doi: 10.3389/fmolb.2022.889719.

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ROS-Influenced Regulatory Cross-Talk With Wnt Signaling Pathway During Perinatal Development.

Chatterjee S , Sil PC .

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Over a century ago, it was found that a rapid burst of oxygen is needed and produced by the sea urchin oocyte to activate fertilization and block polyspermy. Since then, scientific research has taken strides to establish that Reactive Oxygen Species (ROS), besides being toxic effectors of cellular damage and death, also act as molecular messengers in important developmental signaling cascades, thereby modulating them. Wnt signaling pathway is one such developmental pathway, which has significant effects on growth, proliferation, and differentiation of cells at the earliest embryonic stages of an organism, apart from being significant role-players in the instances of cellular transformation and cancer when this tightly-regulated system encounters aberrations. In this review, we discuss more about the Wnt and ROS signaling pathways, how they function, what roles they play overall in animals, and mostly about how these two major signaling systems cross paths and interplay in mediating major cellular signals and executing the predestined changes during the perinatal condition, in a systematic manner.

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References [+] :

Adler, Role of redox potential and reactive oxygen species in stress signaling. 1999, Pubmed

	FIGURE 1. Schematic diagram of the various factors and signaling involved in development of the embryo in utero.
	FIGURE 2. Schematic diagram of the ROS signalling cascade in operation via different modes and pathways.
	FIGURE 3. Schematic diagram of the Wnt signalling pathway in the inactive (left) and the active (right) states.
	FIGURE 4. Schematic diagram showing the crosstalk and interplay of ROS with Wnt.
	FIGURE 5. The different areas afflicted by the implication of ROS during perinatal development.