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ECB-ART-50326
Biosci Biotechnol Biochem July 22, 2022; 86 (8): 1071-1074.
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Functional expression and mutant analysis of thioredoxin-fused CEL-III, a hemolytic lectin from the marine invertebrate Cucumaria echinata.

Shimizu Y , Yonekura M , Kouzuma Y .


Abstract
CEL-III is a hemolytic lectin purified from the marine invertebrate Cucumaria echinata. New expression system of CEL-III was constructed, and the recombinant thioredoxin-fused CEL-III (Trx-CEL-III) showed strong hemolytic and carbohydrate-binding activity as same as authentic CEL-III. Mutation analysis of Trx-CEL-III suggested that carbohydrate binding to subdomain 1α and 2β of CEL-III might be important for the hemolytic activity.

PubMed ID: 35583240
Article link: Biosci Biotechnol Biochem
Grant support: [+]