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Nat Prod Res 2021 Oct 01;3519:3332-3335. doi: 10.1080/14786419.2019.1689496.
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New dihydrobenzofuranoid from the marine-derived fungus Aspergillus ustus KMM 4664.

Oleinikova GK , Zhuravleva OI , Berdyshev DV , Menzorova NI , Popov RS , Denisenko VA , Kirichuk NN , Afiyatullov SS .

One new dihydrobenzofuran derivative (1), known depsipeptide emericellamide A (2), three known drimanes (3-5) and two artifact drimane derivatives (6, 7) were isolated from the marine-derived fungus Aspergillus ustus KMM 4664. Their structures were determined by detailed analysis of spectroscopic data and by comparison with related known compounds. The absolute configuration of 1 was determined by time-dependent density functional theory (TD-DFT) calculations of ECD spectra. Compound 7 showed significant ability of the inhibition of spermatozoa to fertilize egg-cells of the sea urchin Strongylocentrotus intermedius with IC50 value 21 µM.

PubMed ID: 31726858
Article link: Nat Prod Res

Genes referenced: ecd LOC100887844