Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Dev Biol
2020 Mar 15;4592:72-78. doi: 10.1016/j.ydbio.2019.12.011.
Show Gene links
Show Anatomy links
Developmental origin of peripheral ciliary band neurons in the sea urchin embryo.
Slota LA
,
Miranda E
,
Peskin B
,
McClay DR
.
???displayArticle.abstract???
In the sea urchin larva, most neurons lie within an ectodermal region called the ciliary band. Our understanding of the mechanisms of specification and patterning of these peripheral ciliary band neurons is incomplete. Here, we first examine the gene regulatory landscape from which this population of neural progenitors arise in the neuroectoderm. We show that ciliary band neural progenitors first appear in a bilaterally symmetric pattern on the lateral edges of chordin expression in the neuroectoderm. Later in development, these progenitors appear in a salt-and-pepper pattern in the ciliary band where they express soxC, and prox, which are markers of neural specification, and begin to express synaptotagminB, a marker of differentiated neurons. We show that the ciliary band expresses the acid sensing ion channel gene asicl, which suggests that ciliary band neurons control the larva''s ability to discern touch sensitivity. Using a chemical inhibitor of MAPK signaling, we show that this signaling pathway is required for proper specification and patterning of ciliary band neurons. Using live imaging, we show that these neural progenitors undergo small distance migrations in the embryo. We then show that the normal swimming behavior of the larvae is compromised if the neurogenesis pathway is perturbed. The developmental sequence of ciliary band neurons is very similar to that of neural crest-derived sensory neurons in vertebrates and may provide insights into the evolution of sensory neurons in deuterostomes.
Arendt,
From nerve net to nerve ring, nerve cord and brain--evolution of the nervous system.
2016, Pubmed
Arendt,
From nerve net to nerve ring, nerve cord and brain--evolution of the nervous system.
2016,
Pubmed
Bisgrove,
Development of Serotonergic Neurons in Embryos of the Sea Urchin, Strongylocentrotus purpuratus: (serotonergic/neural development/embryo/echinoid).
1986,
Pubmed
,
Echinobase
Bradham,
Chordin is required for neural but not axial development in sea urchin embryos.
2009,
Pubmed
,
Echinobase
Burke,
Sea urchin neural development and the metazoan paradigm of neurogenesis.
2014,
Pubmed
,
Echinobase
Burke,
A genomic view of the sea urchin nervous system.
2006,
Pubmed
,
Echinobase
Choksi,
Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells.
2006,
Pubmed
Deval,
Acid-Sensing Ion Channels and nociception in the peripheral and central nervous systems.
2015,
Pubmed
Duboc,
Nodal and BMP2/4 signaling organizes the oral-aboral axis of the sea urchin embryo.
2004,
Pubmed
,
Echinobase
Garner,
Neurogenesis in sea urchin embryos and the diversity of deuterostome neurogenic mechanisms.
2016,
Pubmed
,
Echinobase
Gonçalves,
Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior.
2016,
Pubmed
Green,
Evolution of vertebrates as viewed from the crest.
2015,
Pubmed
Hinman,
Embryonic neurogenesis in echinoderms.
2018,
Pubmed
,
Echinobase
Kaltenbach,
The origin and migration of the earliest-developing sensory neurons in the peripheral nervous system of amphioxus.
2009,
Pubmed
Lingueglia,
Acid-sensing ion channels in sensory perception.
2007,
Pubmed
McClay,
Neurogenesis in the sea urchin embryo is initiated uniquely in three domains.
2018,
Pubmed
,
Echinobase
Nakajima,
Development and neural organization of the tornaria larva of the Hawaiian hemichordate, Ptychodera flava.
2004,
Pubmed
,
Echinobase
Nieto,
The snail superfamily of zinc-finger transcription factors.
2002,
Pubmed
Röttinger,
A Raf/MEK/ERK signaling pathway is required for development of the sea urchin embryo micromere lineage through phosphorylation of the transcription factor Ets.
2004,
Pubmed
,
Echinobase
Röttinger,
FGF signals guide migration of mesenchymal cells, control skeletal morphogenesis [corrected] and regulate gastrulation during sea urchin development.
2008,
Pubmed
,
Echinobase
Schlosser,
Vertebrate cranial placodes as evolutionary innovations--the ancestor's tale.
2015,
Pubmed
Slota,
Identification of neural transcription factors required for the differentiation of three neuronal subtypes in the sea urchin embryo.
2018,
Pubmed
,
Echinobase
Slota,
Spatial and temporal patterns of gene expression during neurogenesis in the sea urchin Lytechinus variegatus.
2019,
Pubmed
,
Echinobase
Stolfi,
Migratory neuronal progenitors arise from the neural plate borders in tunicates.
2015,
Pubmed
Strathmann,
Time and extent of ciliary response to particles in a non-filtering feeding mechanism.
2007,
Pubmed
,
Echinobase
Wei,
The sea urchin animal pole domain is a Six3-dependent neurogenic patterning center.
2009,
Pubmed
,
Echinobase
Wei,
Direct development of neurons within foregut endoderm of sea urchin embryos.
2011,
Pubmed
,
Echinobase
Wei,
Neurogenic gene regulatory pathways in the sea urchin embryo.
2016,
Pubmed
,
Echinobase
Yaguchi,
Specification of ectoderm restricts the size of the animal plate and patterns neurogenesis in sea urchin embryos.
2006,
Pubmed
,
Echinobase
Yaguchi,
Zinc finger homeobox is required for the differentiation of serotonergic neurons in the sea urchin embryo.
2012,
Pubmed
,
Echinobase
Yaguchi,
Cooperative Wnt-Nodal Signals Regulate the Patterning of Anterior Neuroectoderm.
2016,
Pubmed
,
Echinobase
Yaguchi,
Fez function is required to maintain the size of the animal plate in the sea urchin embryo.
2011,
Pubmed
,
Echinobase
Yu,
The evolutionary origin of the vertebrate neural crest and its developmental gene regulatory network--insights from amphioxus.
2010,
Pubmed
